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- W2034243034 abstract "Abstract. The effect of oral administration of a single dose of 5 mg (6 patients) and 10 mg (6 patients) of LB 46 (Sandoz Ltd., Basel), a new β‐adrenergic antagonist, or placebo (3 patients), on the heart rate and blood pressure at rest and during exercise on a bicycle ergometer has been studied in patients with untreated hyperthyroidism. The two doses had essentially similar effects and decreased the heart rate by about 20% both at rest and during work. There was a marked increase in the calculated physical working capacity at 170 heart beats/min (PWC 170 ) but no significant change in the actual physical working capacity. There was a slight but statistically insignificant decrease in blood pressure. Five mg of LB 46 was given every 8 h for 1 to 3 weeks without any other medication, and the exercise test was then repeated with essentially similar results. Two patients developed transient disturbances of cardiac rhythm during ergometry after 10 mg of LB 46, but all the patients did well during the subsequent continuous administration of the drug. It is concluded that LB 46 is effective in decreasing tachycardia in hyperthyroidism and, mainly in this way, it increases the PWC 170 ." @default.
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- W2034243034 date "1971-01-12" @default.
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- W2034243034 title "EFFECT OF LB 46, A NEW BETA-ADRENERGIC ANTAGONIST, IN HYPERTHYROIDISM" @default.
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- W2034243034 doi "https://doi.org/10.1111/j.0954-6820.1971.tb04400.x" @default.
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