FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034243945> ?p ?o ?g. }

• W2034243945 endingPage "496" @default.
• W2034243945 startingPage "487" @default.
• W2034243945 abstract "The spindle checkpoint delays anaphase onset until all chromosomes have attached properly to the mitotic spindle. Checkpoint signal is generated at kinetochores that are not bound with spindle microtubules or not under tension. Unattached kinetochores associate with several checkpoint proteins, including BubR1, Bub1, Bub3, Mad1, Mad2, and CENP-E. I herein show that BubR1 is important for the spindle checkpoint in Xenopus egg extracts. The protein accumulates and becomes hyperphosphorylated at unattached kinetochores. Immunodepletion of BubR1 greatly reduces kinetochore binding of Bub1, Bub3, Mad1, Mad2, and CENP-E. Loss of BubR1 also impairs the interaction between Mad2, Bub3, and Cdc20, an anaphase activator. These defects are rescued by wild-type, kinase-dead, or a truncated BubR1 that lacks its kinase domain, indicating that the kinase activity of BubR1 is not essential for the spindle checkpoint in egg extracts. Furthermore, localization and hyperphosphorylation of BubR1 at kinetochores are dependent on Bub1 and Mad1, but not Mad2. This paper demonstrates that BubR1 plays an important role in kinetochore association of other spindle checkpoint proteins and that Mad1 facilitates BubR1 hyperphosphorylation at kinetochores." @default.
• W2034243945 created "2016-06-24" @default.
• W2034243945 creator A5082320642 @default.
• W2034243945 date "2002-08-05" @default.
• W2034243945 modified "2023-10-14" @default.
• W2034243945 title "BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1" @default.
• W2034243945 cites W1994177513 @default.
• W2034243945 cites W2005510835 @default.
• W2034243945 cites W2006389406 @default.
• W2034243945 cites W2007074379 @default.
• W2034243945 cites W2010167346 @default.
• W2034243945 cites W2016019304 @default.
• W2034243945 cites W2018711267 @default.
• W2034243945 cites W2027766408 @default.
• W2034243945 cites W2030480153 @default.
• W2034243945 cites W2036390681 @default.
• W2034243945 cites W2048735610 @default.
• W2034243945 cites W2052839307 @default.
• W2034243945 cites W2067519095 @default.
• W2034243945 cites W2067897696 @default.
• W2034243945 cites W2077278757 @default.
• W2034243945 cites W2078358000 @default.
• W2034243945 cites W2088006036 @default.
• W2034243945 cites W2097973787 @default.
• W2034243945 cites W2099257384 @default.
• W2034243945 cites W2106285650 @default.
• W2034243945 cites W2108626462 @default.
• W2034243945 cites W2111069037 @default.
• W2034243945 cites W2111989382 @default.
• W2034243945 cites W2114460232 @default.
• W2034243945 cites W2115275371 @default.
• W2034243945 cites W2119989860 @default.
• W2034243945 cites W2123820544 @default.
• W2034243945 cites W2129543447 @default.
• W2034243945 cites W2136460759 @default.
• W2034243945 cites W2145009672 @default.
• W2034243945 cites W2154241215 @default.
• W2034243945 cites W2161522127 @default.
• W2034243945 cites W2172240299 @default.
• W2034243945 cites W4290260729 @default.
• W2034243945 cites W935855719 @default.
• W2034243945 doi "https://doi.org/10.1083/jcb.200204048" @default.
• W2034243945 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2173820" @default.
• W2034243945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12163471" @default.
• W2034243945 hasPublicationYear "2002" @default.
• W2034243945 type Work @default.
• W2034243945 sameAs 2034243945 @default.
• W2034243945 citedByCount "173" @default.
• W2034243945 countsByYear W20342439452012 @default.
• W2034243945 countsByYear W20342439452013 @default.
• W2034243945 countsByYear W20342439452014 @default.
• W2034243945 countsByYear W20342439452015 @default.
• W2034243945 countsByYear W20342439452016 @default.
• W2034243945 countsByYear W20342439452017 @default.
• W2034243945 countsByYear W20342439452018 @default.
• W2034243945 countsByYear W20342439452019 @default.
• W2034243945 countsByYear W20342439452020 @default.
• W2034243945 countsByYear W20342439452021 @default.
• W2034243945 countsByYear W20342439452022 @default.
• W2034243945 crossrefType "journal-article" @default.
• W2034243945 hasAuthorship W2034243945A5082320642 @default.
• W2034243945 hasBestOaLocation W20342439451 @default.
• W2034243945 hasConcept C104317684 @default.
• W2034243945 hasConcept C105696609 @default.
• W2034243945 hasConcept C107888121 @default.
• W2034243945 hasConcept C141937037 @default.
• W2034243945 hasConcept C1491633281 @default.
• W2034243945 hasConcept C175732170 @default.
• W2034243945 hasConcept C192838845 @default.
• W2034243945 hasConcept C2777563682 @default.
• W2034243945 hasConcept C2780391303 @default.
• W2034243945 hasConcept C29537977 @default.
• W2034243945 hasConcept C30481170 @default.
• W2034243945 hasConcept C53420372 @default.
• W2034243945 hasConcept C54355233 @default.
• W2034243945 hasConcept C86803240 @default.
• W2034243945 hasConcept C95444343 @default.
• W2034243945 hasConceptScore W2034243945C104317684 @default.
• W2034243945 hasConceptScore W2034243945C105696609 @default.
• W2034243945 hasConceptScore W2034243945C107888121 @default.
• W2034243945 hasConceptScore W2034243945C141937037 @default.
• W2034243945 hasConceptScore W2034243945C1491633281 @default.
• W2034243945 hasConceptScore W2034243945C175732170 @default.
• W2034243945 hasConceptScore W2034243945C192838845 @default.
• W2034243945 hasConceptScore W2034243945C2777563682 @default.
• W2034243945 hasConceptScore W2034243945C2780391303 @default.
• W2034243945 hasConceptScore W2034243945C29537977 @default.
• W2034243945 hasConceptScore W2034243945C30481170 @default.
• W2034243945 hasConceptScore W2034243945C53420372 @default.
• W2034243945 hasConceptScore W2034243945C54355233 @default.
• W2034243945 hasConceptScore W2034243945C86803240 @default.
• W2034243945 hasConceptScore W2034243945C95444343 @default.
• W2034243945 hasIssue "3" @default.
• W2034243945 hasLocation W20342439451 @default.
• W2034243945 hasLocation W20342439452 @default.
• W2034243945 hasLocation W20342439453 @default.
• W2034243945 hasLocation W20342439454 @default.
• W2034243945 hasOpenAccess W2034243945 @default.

• next