Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034247645> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2034247645 endingPage "9287" @default.
- W2034247645 startingPage "9278" @default.
- W2034247645 abstract "Natural ligands for nuclear receptors are believed to activate gene transcription by causing dissociation of corepressors and promoting the association of coactivator proteins. Using multiple biophysical techniques, we find that peptides derived from one of the nuclear receptor interacting motifs of the corepressors nuclear receptor corepressor (NCoR) and silencing mediator of retinoid and thyroid receptors (SMRT) are able to bind the ligand binding domains (LBD) of all three PPAR (peroxisome proliferator activated receptor) subtypes. Using these peptides as tools, we find that ligands designed as selective agonists for PPAR gamma promote the association of coactivator peptides and dissociation of corepressor peptides as expected on PPAR gamma but surprisingly have varied effects on the binding of corepressor peptides to the other PPAR subtypes. In particular, some members of a class of L-tyrosine-based compounds designed as selective agonists for PPAR gamma reduce the affinity for corepressor peptides on PPAR gamma but increase the affinity for the same peptides on PPAR delta and in one case on PPAR alpha. We provide structural data that suggests that the molecular basis for these observations are variations in the ligand binding pockets of the three PPAR subtypes that are perturbed differentially by individual ligands and result in altered presentations of the overlapping coactivator/corepressor binding surfaces." @default.
- W2034247645 created "2016-06-24" @default.
- W2034247645 creator A5006954215 @default.
- W2034247645 creator A5011265491 @default.
- W2034247645 creator A5011963950 @default.
- W2034247645 creator A5013624104 @default.
- W2034247645 creator A5036563303 @default.
- W2034247645 creator A5052217844 @default.
- W2034247645 creator A5062942262 @default.
- W2034247645 creator A5067293400 @default.
- W2034247645 creator A5070648904 @default.
- W2034247645 creator A5079082088 @default.
- W2034247645 date "2003-07-15" @default.
- W2034247645 modified "2023-09-28" @default.
- W2034247645 title "Subtype Specific Effects of Peroxisome Proliferator-Activated Receptor Ligands on Corepressor Affinity" @default.
- W2034247645 cites W1566461714 @default.
- W2034247645 cites W1977666051 @default.
- W2034247645 cites W1987652896 @default.
- W2034247645 cites W2026441085 @default.
- W2034247645 cites W2052804781 @default.
- W2034247645 cites W2060696024 @default.
- W2034247645 cites W2081846665 @default.
- W2034247645 doi "https://doi.org/10.1021/bi034472c" @default.
- W2034247645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12899614" @default.
- W2034247645 hasPublicationYear "2003" @default.
- W2034247645 type Work @default.
- W2034247645 sameAs 2034247645 @default.
- W2034247645 citedByCount "40" @default.
- W2034247645 countsByYear W20342476452012 @default.
- W2034247645 countsByYear W20342476452013 @default.
- W2034247645 countsByYear W20342476452014 @default.
- W2034247645 countsByYear W20342476452015 @default.
- W2034247645 countsByYear W20342476452016 @default.
- W2034247645 countsByYear W20342476452017 @default.
- W2034247645 crossrefType "journal-article" @default.
- W2034247645 hasAuthorship W2034247645A5006954215 @default.
- W2034247645 hasAuthorship W2034247645A5011265491 @default.
- W2034247645 hasAuthorship W2034247645A5011963950 @default.
- W2034247645 hasAuthorship W2034247645A5013624104 @default.
- W2034247645 hasAuthorship W2034247645A5036563303 @default.
- W2034247645 hasAuthorship W2034247645A5052217844 @default.
- W2034247645 hasAuthorship W2034247645A5062942262 @default.
- W2034247645 hasAuthorship W2034247645A5067293400 @default.
- W2034247645 hasAuthorship W2034247645A5070648904 @default.
- W2034247645 hasAuthorship W2034247645A5079082088 @default.
- W2034247645 hasConcept C104317684 @default.
- W2034247645 hasConcept C146777309 @default.
- W2034247645 hasConcept C170493617 @default.
- W2034247645 hasConcept C185592680 @default.
- W2034247645 hasConcept C187345961 @default.
- W2034247645 hasConcept C55493867 @default.
- W2034247645 hasConcept C63932345 @default.
- W2034247645 hasConcept C77445288 @default.
- W2034247645 hasConcept C86339819 @default.
- W2034247645 hasConcept C86803240 @default.
- W2034247645 hasConcept C95444343 @default.
- W2034247645 hasConceptScore W2034247645C104317684 @default.
- W2034247645 hasConceptScore W2034247645C146777309 @default.
- W2034247645 hasConceptScore W2034247645C170493617 @default.
- W2034247645 hasConceptScore W2034247645C185592680 @default.
- W2034247645 hasConceptScore W2034247645C187345961 @default.
- W2034247645 hasConceptScore W2034247645C55493867 @default.
- W2034247645 hasConceptScore W2034247645C63932345 @default.
- W2034247645 hasConceptScore W2034247645C77445288 @default.
- W2034247645 hasConceptScore W2034247645C86339819 @default.
- W2034247645 hasConceptScore W2034247645C86803240 @default.
- W2034247645 hasConceptScore W2034247645C95444343 @default.
- W2034247645 hasIssue "31" @default.
- W2034247645 hasLocation W20342476451 @default.
- W2034247645 hasLocation W20342476452 @default.
- W2034247645 hasOpenAccess W2034247645 @default.
- W2034247645 hasPrimaryLocation W20342476451 @default.
- W2034247645 hasRelatedWork W2020852287 @default.
- W2034247645 hasRelatedWork W2021520674 @default.
- W2034247645 hasRelatedWork W2034247645 @default.
- W2034247645 hasRelatedWork W2068733538 @default.
- W2034247645 hasRelatedWork W2068895932 @default.
- W2034247645 hasRelatedWork W2089270738 @default.
- W2034247645 hasRelatedWork W2108345134 @default.
- W2034247645 hasRelatedWork W2122486961 @default.
- W2034247645 hasRelatedWork W2169726677 @default.
- W2034247645 hasRelatedWork W2791959216 @default.
- W2034247645 hasVolume "42" @default.
- W2034247645 isParatext "false" @default.
- W2034247645 isRetracted "false" @default.
- W2034247645 magId "2034247645" @default.
- W2034247645 workType "article" @default.