FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034248586> ?p ?o ?g. }

• W2034248586 endingPage "128" @default.
• W2034248586 startingPage "118" @default.
• W2034248586 abstract "Nephrin is an immunoglobulin-like adhesion molecule first discovered as a major component of the podocyte slit diaphragm, where its integrity is essential to the function of the glomerular filtration barrier. Outside the kidney, nephrin has been shown in other restricted locations, most notably in the central nervous system (CNS) of embryonic and newborn rodents. With the aim of better characterizing nephrin expression and its role in the CNS of adult rodents, we studied its expression pattern and possible binding partners in CNS tissues and cultured neuronal cells and compared these data to those obtained in control renal tissues and podocyte cell cultures. Our results show that, besides a number of locations already found in embryos and newborns, endogenous nephrin in adult rodent CNS extends to the pons and corpus callosum and is expressed by granule cells and Purkinje cells of the cerebellum, with a characteristic alternating expression pattern. In primary neuronal cells we find nephrin expression close to synaptic proteins and demonstrate that nephrin co-immunoprecipitates with Fyn kinase, glutamate receptors and the scaffolding molecule PSD95, an assembly that is reminiscent of those made by synaptic adhesion molecules. This role seems to be confirmed by our findings of impaired maturation and reduced glutamate exocytosis occurring in Neuro2A cells upon nephrin silencing. Of note, we disclose that the very same nephrin interactions occur in renal glomeruli and cultured podocytes, supporting our hypothesis that podocytes organize and use similar molecular intercellular signalling modules to those used by neuronal cells." @default.
• W2034248586 created "2016-06-24" @default.
• W2034248586 creator A5004804603 @default.
• W2034248586 creator A5011863838 @default.
• W2034248586 creator A5014970553 @default.
• W2034248586 creator A5036673975 @default.
• W2034248586 creator A5037151999 @default.
• W2034248586 creator A5058112945 @default.
• W2034248586 creator A5064594935 @default.
• W2034248586 creator A5066042051 @default.
• W2034248586 creator A5066785571 @default.
• W2034248586 creator A5070949543 @default.
• W2034248586 creator A5073453050 @default.
• W2034248586 creator A5073844666 @default.
• W2034248586 creator A5084544899 @default.
• W2034248586 creator A5088714561 @default.
• W2034248586 creator A5089617545 @default.
• W2034248586 date "2011-06-01" @default.
• W2034248586 modified "2023-10-03" @default.
• W2034248586 title "Nephrin expression in adult rodent central nervous system and its interaction with glutamate receptors" @default.
• W2034248586 cites W1564285111 @default.
• W2034248586 cites W1629086159 @default.
• W2034248586 cites W1967772460 @default.
• W2034248586 cites W1967853257 @default.
• W2034248586 cites W1972845034 @default.
• W2034248586 cites W1973712279 @default.
• W2034248586 cites W1975401614 @default.
• W2034248586 cites W1979865400 @default.
• W2034248586 cites W1984322158 @default.
• W2034248586 cites W1985420557 @default.
• W2034248586 cites W1988170371 @default.
• W2034248586 cites W1991449336 @default.
• W2034248586 cites W2004010528 @default.
• W2034248586 cites W2009368968 @default.
• W2034248586 cites W2017489719 @default.
• W2034248586 cites W2024222737 @default.
• W2034248586 cites W2024431713 @default.
• W2034248586 cites W2030110080 @default.
• W2034248586 cites W2040425750 @default.
• W2034248586 cites W2049804001 @default.
• W2034248586 cites W2058538624 @default.
• W2034248586 cites W2059946666 @default.
• W2034248586 cites W2067561211 @default.
• W2034248586 cites W2076858966 @default.
• W2034248586 cites W2079832984 @default.
• W2034248586 cites W2082390023 @default.
• W2034248586 cites W2085591555 @default.
• W2034248586 cites W2088239473 @default.
• W2034248586 cites W2089809296 @default.
• W2034248586 cites W2090048264 @default.
• W2034248586 cites W2090501101 @default.
• W2034248586 cites W2093573816 @default.
• W2034248586 cites W2093862824 @default.
• W2034248586 cites W2096672118 @default.
• W2034248586 cites W2097573588 @default.
• W2034248586 cites W2098596246 @default.
• W2034248586 cites W2100414555 @default.
• W2034248586 cites W2107763864 @default.
• W2034248586 cites W2108206329 @default.
• W2034248586 cites W2108485136 @default.
• W2034248586 cites W2110701772 @default.
• W2034248586 cites W2116986223 @default.
• W2034248586 cites W2118491944 @default.
• W2034248586 cites W2125779862 @default.
• W2034248586 cites W2128625570 @default.
• W2034248586 cites W2136558879 @default.
• W2034248586 cites W2153534186 @default.
• W2034248586 cites W2154261062 @default.
• W2034248586 cites W2156059816 @default.
• W2034248586 cites W2157372215 @default.
• W2034248586 cites W2158306086 @default.
• W2034248586 cites W2160944895 @default.
• W2034248586 cites W2172150005 @default.
• W2034248586 cites W2242644643 @default.
• W2034248586 doi "https://doi.org/10.1002/path.2923" @default.
• W2034248586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21630272" @default.
• W2034248586 hasPublicationYear "2011" @default.
• W2034248586 type Work @default.
• W2034248586 sameAs 2034248586 @default.
• W2034248586 citedByCount "29" @default.
• W2034248586 countsByYear W20342485862012 @default.
• W2034248586 countsByYear W20342485862013 @default.
• W2034248586 countsByYear W20342485862014 @default.
• W2034248586 countsByYear W20342485862015 @default.
• W2034248586 countsByYear W20342485862016 @default.
• W2034248586 countsByYear W20342485862017 @default.
• W2034248586 countsByYear W20342485862018 @default.
• W2034248586 countsByYear W20342485862019 @default.
• W2034248586 countsByYear W20342485862020 @default.
• W2034248586 countsByYear W20342485862021 @default.
• W2034248586 countsByYear W20342485862022 @default.
• W2034248586 countsByYear W20342485862023 @default.
• W2034248586 crossrefType "journal-article" @default.
• W2034248586 hasAuthorship W2034248586A5004804603 @default.
• W2034248586 hasAuthorship W2034248586A5011863838 @default.
• W2034248586 hasAuthorship W2034248586A5014970553 @default.
• W2034248586 hasAuthorship W2034248586A5036673975 @default.
• W2034248586 hasAuthorship W2034248586A5037151999 @default.

• next