FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034248906> ?p ?o ?g. }

• W2034248906 abstract "Promoter genomic DNA methylation is an important inactivation mechanism of tumor suppressor genes. This genetic-molecular pathway for cancer may separate a subset of patients with different prognoses and eventually different responses to specific therapies.To analyze the methylation pattern of important genes related to different carcinogenic mechanisms in patients with gastric cancer (GC) and the relationship with its morphological features and biological behavior.Forty-seven fresh-frozen GC samples were selected. The methylation-specific PCR (MSP) test was used to analyze promoter methylation status for genes MLH1, CDKN2A (p16), APC, CDH1 (Cadherin E) and FHIT. Follow-up and complete morphological features were obtained for all cases.We found methylation in at least one of the genes studied in 83% of the cases. The frequencies of promoter hypermethylation of MLH1, CDKN2A, APC, CDH1 and FHIT were 31%, 43%, 46%, 80% y 62%, respectively. We found a relationship between APC methylation and good histological differentiation (p =0.03); CDH1 methylation with diffuse type by Lauren and 3 or more metastasic lymph nodes (p <0.05); FHIT, CDKN2A and CDH1 methylation and female condition (p <0.04). We also found a non-significant relationship between CDKN2A methylation and better survival (p =0.07).The high frequency promoter methylation found confirms its importance in gastric carcinogenesis. The finding of alterations in the methylation pattern of genes studied and its association with prognostic factors is a helpful tool in the search for new criteria in clinical and therapeutic decision making." @default.
• W2034248906 created "2016-06-24" @default.
• W2034248906 creator A5017667826 @default.
• W2034248906 creator A5032833151 @default.
• W2034248906 creator A5041278722 @default.
• W2034248906 creator A5050852442 @default.
• W2034248906 creator A5072561167 @default.
• W2034248906 creator A5074372629 @default.
• W2034248906 creator A5074982568 @default.
• W2034248906 date "2005-08-01" @default.
• W2034248906 modified "2023-09-23" @default.
• W2034248906 title "Estudio del patrón de metilación génico en el cáncer gástrico en Chile" @default.
• W2034248906 cites W1556996865 @default.
• W2034248906 cites W1601758517 @default.
• W2034248906 cites W1658127082 @default.
• W2034248906 cites W1761725668 @default.
• W2034248906 cites W1977706798 @default.
• W2034248906 cites W1988682473 @default.
• W2034248906 cites W1994465394 @default.
• W2034248906 cites W2022741840 @default.
• W2034248906 cites W2040149948 @default.
• W2034248906 cites W2044643325 @default.
• W2034248906 cites W2049489582 @default.
• W2034248906 cites W2051966279 @default.
• W2034248906 cites W2060647968 @default.
• W2034248906 cites W2077475263 @default.
• W2034248906 cites W2082396164 @default.
• W2034248906 cites W2109881276 @default.
• W2034248906 cites W2130500105 @default.
• W2034248906 cites W2148885171 @default.
• W2034248906 cites W2159170690 @default.
• W2034248906 cites W2165056748 @default.
• W2034248906 cites W2324313493 @default.
• W2034248906 cites W2430460587 @default.
• W2034248906 cites W1767260886 @default.
• W2034248906 doi "https://doi.org/10.4067/s0034-98872005000800002" @default.
• W2034248906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16163424" @default.
• W2034248906 hasPublicationYear "2005" @default.
• W2034248906 type Work @default.
• W2034248906 sameAs 2034248906 @default.
• W2034248906 citedByCount "6" @default.
• W2034248906 countsByYear W20342489062015 @default.
• W2034248906 countsByYear W20342489062017 @default.
• W2034248906 crossrefType "journal-article" @default.
• W2034248906 hasAuthorship W2034248906A5017667826 @default.
• W2034248906 hasAuthorship W2034248906A5032833151 @default.
• W2034248906 hasAuthorship W2034248906A5041278722 @default.
• W2034248906 hasAuthorship W2034248906A5050852442 @default.
• W2034248906 hasAuthorship W2034248906A5072561167 @default.
• W2034248906 hasAuthorship W2034248906A5074372629 @default.
• W2034248906 hasAuthorship W2034248906A5074982568 @default.
• W2034248906 hasBestOaLocation W20342489061 @default.
• W2034248906 hasConcept C101762097 @default.
• W2034248906 hasConcept C104317684 @default.
• W2034248906 hasConcept C111425858 @default.
• W2034248906 hasConcept C121608353 @default.
• W2034248906 hasConcept C134935766 @default.
• W2034248906 hasConcept C1491633281 @default.
• W2034248906 hasConcept C149402561 @default.
• W2034248906 hasConcept C150194340 @default.
• W2034248906 hasConcept C153911025 @default.
• W2034248906 hasConcept C190727270 @default.
• W2034248906 hasConcept C2776391639 @default.
• W2034248906 hasConcept C2778264664 @default.
• W2034248906 hasConcept C2780265364 @default.
• W2034248906 hasConcept C2780646079 @default.
• W2034248906 hasConcept C33288867 @default.
• W2034248906 hasConcept C41091548 @default.
• W2034248906 hasConcept C502942594 @default.
• W2034248906 hasConcept C54355233 @default.
• W2034248906 hasConcept C555283112 @default.
• W2034248906 hasConcept C60748783 @default.
• W2034248906 hasConcept C86803240 @default.
• W2034248906 hasConceptScore W2034248906C101762097 @default.
• W2034248906 hasConceptScore W2034248906C104317684 @default.
• W2034248906 hasConceptScore W2034248906C111425858 @default.
• W2034248906 hasConceptScore W2034248906C121608353 @default.
• W2034248906 hasConceptScore W2034248906C134935766 @default.
• W2034248906 hasConceptScore W2034248906C1491633281 @default.
• W2034248906 hasConceptScore W2034248906C149402561 @default.
• W2034248906 hasConceptScore W2034248906C150194340 @default.
• W2034248906 hasConceptScore W2034248906C153911025 @default.
• W2034248906 hasConceptScore W2034248906C190727270 @default.
• W2034248906 hasConceptScore W2034248906C2776391639 @default.
• W2034248906 hasConceptScore W2034248906C2778264664 @default.
• W2034248906 hasConceptScore W2034248906C2780265364 @default.
• W2034248906 hasConceptScore W2034248906C2780646079 @default.
• W2034248906 hasConceptScore W2034248906C33288867 @default.
• W2034248906 hasConceptScore W2034248906C41091548 @default.
• W2034248906 hasConceptScore W2034248906C502942594 @default.
• W2034248906 hasConceptScore W2034248906C54355233 @default.
• W2034248906 hasConceptScore W2034248906C555283112 @default.
• W2034248906 hasConceptScore W2034248906C60748783 @default.
• W2034248906 hasConceptScore W2034248906C86803240 @default.
• W2034248906 hasIssue "8" @default.
• W2034248906 hasLocation W20342489061 @default.
• W2034248906 hasLocation W20342489062 @default.
• W2034248906 hasOpenAccess W2034248906 @default.
• W2034248906 hasPrimaryLocation W20342489061 @default.
• W2034248906 hasRelatedWork W1980915468 @default.

• next