Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034249062> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2034249062 endingPage "74" @default.
- W2034249062 startingPage "71" @default.
- W2034249062 abstract "Chronic renal failure (CRF) is characterized by persistent systemic inflammatory response. We tested the hypothesis that the balance between synthetic capacity of pro-inflammatory, as tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, and anti-inflammatory cytokines, as IL-10, may become progressively impaired during decline of renal function. Cytokine mRNA transcript levels (fraction of GAPDH mRNA) were detected by real time RT-PCR technique in whole blood cells of patients with far-advanced or less-advanced CRF (glomerular filtration rate lower or greater than 15ml/min per 1.73m(2), respectively) undergoing conservative treatment and in healthy controls. TNF-alpha mRNA levels were greater (p<0.05) in the patients with far-advanced CRF than in those with less-advanced CRF. IL-6 mRNA levels were not significantly different in the two groups. Both groups of patients exhibited greater (p<0.05) TNF-alpha and IL-6 mRNA levels than the healthy controls. IL-10 mRNA levels were greater (p<0.05) in the patients with less-advanced CRF (65+/-18) than in the healthy controls (12+/-2). Nonetheless, in the patients with far-advanced CRF, IL-10 mRNA levels (20+/-10) were lower (p<0.05) than in the patients with less-advanced CRF and not significantly different than in the healthy controls. In conclusion, advanced renal failure is characterized by unbalanced synthetic capacity of pro- and anti-inflammatory cytokines. A progressive decrease in IL-10 synthetic capacity during the course of CRF could contribute to increasing cardiovascular risk." @default.
- W2034249062 created "2016-06-24" @default.
- W2034249062 creator A5013649375 @default.
- W2034249062 creator A5025489246 @default.
- W2034249062 creator A5040625595 @default.
- W2034249062 creator A5081926215 @default.
- W2034249062 creator A5086417559 @default.
- W2034249062 date "2007-11-01" @default.
- W2034249062 modified "2023-09-24" @default.
- W2034249062 title "Decreased IL-10 mRNA expression in patients with advanced renal failure undergoing conservative treatment" @default.
- W2034249062 cites W1979517335 @default.
- W2034249062 cites W1988486293 @default.
- W2034249062 cites W1988838772 @default.
- W2034249062 cites W1993419005 @default.
- W2034249062 cites W1998793192 @default.
- W2034249062 cites W2016154097 @default.
- W2034249062 cites W2030401333 @default.
- W2034249062 cites W2042945134 @default.
- W2034249062 cites W2048302860 @default.
- W2034249062 cites W2065181541 @default.
- W2034249062 cites W2093716569 @default.
- W2034249062 cites W2110708445 @default.
- W2034249062 cites W2127191881 @default.
- W2034249062 cites W2166452986 @default.
- W2034249062 doi "https://doi.org/10.1016/j.cyto.2007.09.002" @default.
- W2034249062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17933548" @default.
- W2034249062 hasPublicationYear "2007" @default.
- W2034249062 type Work @default.
- W2034249062 sameAs 2034249062 @default.
- W2034249062 citedByCount "9" @default.
- W2034249062 countsByYear W20342490622012 @default.
- W2034249062 countsByYear W20342490622013 @default.
- W2034249062 countsByYear W20342490622017 @default.
- W2034249062 countsByYear W20342490622018 @default.
- W2034249062 crossrefType "journal-article" @default.
- W2034249062 hasAuthorship W2034249062A5013649375 @default.
- W2034249062 hasAuthorship W2034249062A5025489246 @default.
- W2034249062 hasAuthorship W2034249062A5040625595 @default.
- W2034249062 hasAuthorship W2034249062A5081926215 @default.
- W2034249062 hasAuthorship W2034249062A5086417559 @default.
- W2034249062 hasConcept C104317684 @default.
- W2034249062 hasConcept C105580179 @default.
- W2034249062 hasConcept C126322002 @default.
- W2034249062 hasConcept C134018914 @default.
- W2034249062 hasConcept C134792803 @default.
- W2034249062 hasConcept C141071460 @default.
- W2034249062 hasConcept C159641895 @default.
- W2034249062 hasConcept C164027704 @default.
- W2034249062 hasConcept C17991360 @default.
- W2034249062 hasConcept C2775944032 @default.
- W2034249062 hasConcept C2776914184 @default.
- W2034249062 hasConcept C2778690821 @default.
- W2034249062 hasConcept C2780306776 @default.
- W2034249062 hasConcept C2993356106 @default.
- W2034249062 hasConcept C49453240 @default.
- W2034249062 hasConcept C55493867 @default.
- W2034249062 hasConcept C64943373 @default.
- W2034249062 hasConcept C71924100 @default.
- W2034249062 hasConcept C86803240 @default.
- W2034249062 hasConceptScore W2034249062C104317684 @default.
- W2034249062 hasConceptScore W2034249062C105580179 @default.
- W2034249062 hasConceptScore W2034249062C126322002 @default.
- W2034249062 hasConceptScore W2034249062C134018914 @default.
- W2034249062 hasConceptScore W2034249062C134792803 @default.
- W2034249062 hasConceptScore W2034249062C141071460 @default.
- W2034249062 hasConceptScore W2034249062C159641895 @default.
- W2034249062 hasConceptScore W2034249062C164027704 @default.
- W2034249062 hasConceptScore W2034249062C17991360 @default.
- W2034249062 hasConceptScore W2034249062C2775944032 @default.
- W2034249062 hasConceptScore W2034249062C2776914184 @default.
- W2034249062 hasConceptScore W2034249062C2778690821 @default.
- W2034249062 hasConceptScore W2034249062C2780306776 @default.
- W2034249062 hasConceptScore W2034249062C2993356106 @default.
- W2034249062 hasConceptScore W2034249062C49453240 @default.
- W2034249062 hasConceptScore W2034249062C55493867 @default.
- W2034249062 hasConceptScore W2034249062C64943373 @default.
- W2034249062 hasConceptScore W2034249062C71924100 @default.
- W2034249062 hasConceptScore W2034249062C86803240 @default.
- W2034249062 hasIssue "2" @default.
- W2034249062 hasLocation W20342490621 @default.
- W2034249062 hasLocation W20342490622 @default.
- W2034249062 hasOpenAccess W2034249062 @default.
- W2034249062 hasPrimaryLocation W20342490621 @default.
- W2034249062 hasRelatedWork W1835699834 @default.
- W2034249062 hasRelatedWork W1969011799 @default.
- W2034249062 hasRelatedWork W1977918131 @default.
- W2034249062 hasRelatedWork W1980194808 @default.
- W2034249062 hasRelatedWork W1987697173 @default.
- W2034249062 hasRelatedWork W1990717759 @default.
- W2034249062 hasRelatedWork W2021930415 @default.
- W2034249062 hasRelatedWork W2034985166 @default.
- W2034249062 hasRelatedWork W3031698746 @default.
- W2034249062 hasRelatedWork W4254218321 @default.
- W2034249062 hasVolume "40" @default.
- W2034249062 isParatext "false" @default.
- W2034249062 isRetracted "false" @default.
- W2034249062 magId "2034249062" @default.
- W2034249062 workType "article" @default.