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- W2034249568 abstract "Epinephrine (Epi) stimulated liver glycogenolysis is mediated by cAMP independent α-mechanism in the adult rat as opposed to cAMP dependent β-mechanism in perinatal rat. However the mechanism and timing of β→α switchover is unclear. Alpha receptor stimulation increases plasma membrane phosphatidylinositol (PI) turnover which subsequently leads to glycogen phosphorylase (GP) stimulation. We examined ontogeny of adrenergic stimulated cAMP, PI phosphorylation and GP in newborn hepatocytes. Epi stimulated cAMP was 7 times higher (P<0.01) but PI phosphorylation was 54% lower (P<0.01) at 5 day than adult. GP stimulation by α and β mechanisms in Control and PTU treated (17d gestation on) rats were: GP expressed as hormone stimulation/basal (M±SE%). n=6-8 each. Phe:phentolamine, Alp; alprenolol. *:Control>PTU P<0.03. §:Adult <5, 15, 28 day P<0.01. Δ:Adult>5, 15 d P<0.01. We conclude that Epi stimulated glycogenolysis is totally mediated by cAMP-β mechanism before 15 days, 2) ontogeny of α but not β mechanism is regulated by thyroid hormone during postnatal period. We speculate that the low but present PI phosphorylation despite total lack of α-mediated GP before 15 days indicates receptor as well as post-PI site are involved in the maturational process of α-adrenergic mechanism in the rat liver." @default.
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- W2034249568 date "1984-04-01" @default.
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- W2034249568 title "POSTNATAL MATURATION OF α-ADRENERGIC MECHANISM IN THE NEWBORN RAT LIVER" @default.
- W2034249568 doi "https://doi.org/10.1203/00006450-198404001-00302" @default.
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