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• W2034249705 abstract "There is growing evidence that stress and other behavioral factors may affect cancer progression and patient survival. The underlying mechanisms for this association are poorly understood. The purpose of this study is to determine the effects of stress-associated hormones norepinephrine, epinephrine, and cortisol on the invasive potential of ovarian cancer cells.The ovarian cancer cells EG, SKOV3, and 222 were exposed to increasing levels of either norepinephrine, epinephrine, or cortisol, and the in vitro invasive potential was determined using the membrane invasion culture system. Additionally, the effects of these stress hormones on matrix metalloproteinase-2 (MMP-2) and MMP-9 were determined by ELISA. The effects of the beta-adrenergic agonist isoproterenol on in vivo tumor growth were determined using nude mice.Stress levels of norepinephrine increased the in vitro invasiveness of ovarian cancer cells by 89% to 198%. Epinephrine also induced significant increases in invasion in all three cell lines ranging from 64% to 76%. Cortisol did not significantly affect invasiveness of the EG and 222 cell lines but increased invasion in the SKOV3 cell line (P = 0.01). We have previously shown that ovarian cancer cells express beta-adrenergic receptors. The beta-adrenergic antagonist propanolol (1 mumol/L) completely blocked the norepinephrine-induced increase in invasiveness. Norepinephrine also increased tumor cell expression of MMP-2 (P = 0.02 for both SKOV3 and EG cells) and MMP-9 (P = 0.01 and 0.04, respectively), and pharmacologic blockade of MMPs abrogated the effects of norepinephrine on tumor cell invasive potential. Isoproterenol treatment resulted in a significant increase in tumor volume and infiltration in the SKOV3ip1 in vivo model, which was blocked by propranolol.These findings provide direct experimental evidence that stress hormones can enhance the invasive potential of ovarian cancer cells. These effects are most likely mediated by stimulation of MMPs." @default.
• W2034249705 created "2016-06-24" @default.
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• W2034249705 date "2006-01-15" @default.
• W2034249705 modified "2023-10-17" @default.
• W2034249705 title "Stress Hormone–Mediated Invasion of Ovarian Cancer Cells" @default.
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• W2034249705 cites W1514373827 @default.
• W2034249705 cites W1516077090 @default.
• W2034249705 cites W1520207918 @default.
• W2034249705 cites W1520425169 @default.
• W2034249705 cites W1574172480 @default.
• W2034249705 cites W1656339735 @default.
• W2034249705 cites W1927670162 @default.
• W2034249705 cites W1964624554 @default.
• W2034249705 cites W1976600474 @default.
• W2034249705 cites W1983609115 @default.
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• W2034249705 cites W1991267517 @default.
• W2034249705 cites W1992642151 @default.
• W2034249705 cites W1995425704 @default.
• W2034249705 cites W1999033679 @default.
• W2034249705 cites W2000776761 @default.
• W2034249705 cites W2004561060 @default.
• W2034249705 cites W2004702770 @default.
• W2034249705 cites W2012977472 @default.
• W2034249705 cites W2013675394 @default.
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• W2034249705 cites W2032140254 @default.
• W2034249705 cites W2034139245 @default.
• W2034249705 cites W2036603780 @default.
• W2034249705 cites W2042397276 @default.
• W2034249705 cites W2042570351 @default.
• W2034249705 cites W2043115926 @default.
• W2034249705 cites W2046244888 @default.
• W2034249705 cites W2048126551 @default.
• W2034249705 cites W2058404220 @default.
• W2034249705 cites W2059196682 @default.
• W2034249705 cites W2063757122 @default.
• W2034249705 cites W2067216288 @default.
• W2034249705 cites W2071507111 @default.
• W2034249705 cites W2074595095 @default.
• W2034249705 cites W2076832092 @default.
• W2034249705 cites W2079508342 @default.
• W2034249705 cites W2084887339 @default.
• W2034249705 cites W2085241964 @default.
• W2034249705 cites W2091295863 @default.
• W2034249705 cites W2104873025 @default.
• W2034249705 cites W2109658199 @default.
• W2034249705 cites W2113763207 @default.
• W2034249705 cites W2116305904 @default.
• W2034249705 cites W2123908823 @default.
• W2034249705 cites W2132539548 @default.
• W2034249705 cites W2144409619 @default.
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• W2034249705 cites W2169685423 @default.
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• W2034249705 cites W2417563252 @default.
• W2034249705 cites W4210769648 @default.
• W2034249705 cites W4247325192 @default.
• W2034249705 cites W4255304519 @default.
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• W2034249705 doi "https://doi.org/10.1158/1078-0432.ccr-05-1698" @default.
• W2034249705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3141061" @default.
• W2034249705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16428474" @default.
• W2034249705 hasPublicationYear "2006" @default.
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