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- W2034251946 abstract "Abstract Purpose: Ischemia/reperfusion of the small intestine disrupts gut barrier function and activates systemic inflammation. The anti-inflammatory cytokine interleukin-10 (IL-10) is protective in murine models of acute sepsis, yet its role during gut injury is unknown. We therefore undertook to investigate this question. Methods: Mice genetically deficient in IL-10 (IL-10 −/− ) on a C57BL/10 background, their wild-type littermates, and Balb/c mice underwent 30 to 80 minutes of occlusion of the superior mesenteric artery. Sixteen hours after reperfusion, survival was documented and the small bowel scored for histologic damage. Results: The LD 50 of IL-10 −/− mice was 35 minutes of occlusion, identical to that of the wild-type mice. The small bowel of all animals that died was distended, with localized jejunal hemorrhage. LD 50 Occlusion (min) Histologic Injury Score (n = 3) C57BL/10 (IL-10 +/+ ) 35 30 3.0 ± 1.0 C57BL/10 (IL-10 −/− ) 35 30 2.0 ± 0.0 Balb/c 60 50 4.3 ± 4.0 Balb/c 60 20 0.3 ± 0.6 No significant difference in intestinal damage was observed between surviving IL-10 −/− and IL-10 +/+ mice after 30 minutes of occlusion. Balb/c mice were more resistant to intestinal ischemia, demonstrated by an LD 50 at 60 minutes of occlusion. Furthermore, equivalent mucosal damage in Balb/c mice required 50 minutes of occlusion as compared with that seen in 30 minutes with occluded C57BL/10 mice. Conclusions: Interleukin-10 does not play a significant protective role either locally or systemically in this model of ischemia/reperfusion. The resistance of the Balb/c strain suggests that an alternate mechanism modulates the response to intestinal ischemic/reperfusion injury." @default.
- W2034251946 created "2016-06-24" @default.
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- W2034251946 date "1999-09-01" @default.
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- W2034251946 title "Endogenous interleukin 10 does not protect against local or systemic injury in a murine model of intestinal ischemia and reperfusion 1 1The Society of Black Academic Surgeons expresses its appreciation to Dr. Walter Pories and the editorial staff of Current Surgery for their interest in the Society and the publication of these abstracts." @default.
- W2034251946 doi "https://doi.org/10.1016/s0149-7944(99)00148-8" @default.
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