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• W2034252719 startingPage "71" @default.
• W2034252719 abstract "Natural killer (NK) cells are important effectors in resistance to viral infections. The role of NK cells in the acute response to human immunodeficiency virus 1 (HIV-1) infected cells was investigated in a mouse model based on a HIV-1/murine leukemia virus (MuLV) pseudovirus. Splenocytes infected with HIV-1/MuLV were injected intraperitoneally and local immunologic responses and persistence of infected cells were investigated. In vivo depletion with an anti-NK1.1 antibody showed that NK cells are important in resistance to virus infected cells. Moreover, NK cell frequency in the peritoneal cavity increased in response to infected cells and these NK cells had a more mature phenotype, as determined by CD27 and Mac-1 expression. Interestingly, after injection of HIV-1/MuLV infected cells, but not MuLV infected cells, peritoneal NK cells had an increased cytotoxic activity. In conclusion, NK cells play a role in the early control of HIV-1/MuLV infected cells in vivo." @default.
• W2034252719 created "2016-06-24" @default.
• W2034252719 creator A5004527390 @default.
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• W2034252719 date "2011-01-01" @default.
• W2034252719 modified "2023-09-30" @default.
• W2034252719 title "Accumulation and activation of natural killer cells in local intraperitoneal HIV-1/MuLV infection results in early control of virus infected cells" @default.
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• W2034252719 doi "https://doi.org/10.1016/j.cellimm.2011.09.005" @default.
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• W2034252719 hasPublicationYear "2011" @default.
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