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- W2034253677 abstract "The pharmacokinetics of ceftezole, a new cephalosporin antibiotic, was studied in 15 patients with normal and impaired renal function after administering the drug in a 2-hour intravenous drip infusion of 2 g. 81% of the infused dose was excreted in the first 6 h urine of the patients with normal renal function. The pharmacokinetic parameters of ceftezole were obtained by analyzing the serum level data of the drug using a one-compartment open model. The mean serum half-life of ceftezole was 0.64 h in patients with normal renal function and was prolonged to 10.7 h in patients with severely impaired renal function (creatinine clearance: 0-2.6 ml/min.). There was a significant linear correlation between the elimination rate of the drug and creatinine clearance." @default.
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- W2034253677 date "1980-01-01" @default.
- W2034253677 modified "2023-09-28" @default.
- W2034253677 title "Pharmacokinetics of Ceftezole in Patients with Normal and Impaired Renal Function" @default.
- W2034253677 doi "https://doi.org/10.1159/000237912" @default.
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