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• W2034256265 abstract "Dithiolethiones upregulate the expression of cancer-preventive proteins via modification of thiol residues in the Keap1-Nrf2 transcription factor complex. In addition to Keap1-Nrf2, dithiolethiones have the potential to modify a variety of cysteine-containing proteins in the cell. Such 'off target' reactions could contribute to either side effects or cancer-preventive efficacy. Evidence is presented here that cancer chemopreventive dithiolethiones inactivate protein tyrosine phosphatases via covalent, but thiol-labile, modification of active site residues. This observation may explain a number of previously reported cellular responses to dithiolethiones." @default.
• W2034256265 created "2016-06-24" @default.
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• W2034256265 date "2010-08-01" @default.
• W2034256265 modified "2023-10-18" @default.
• W2034256265 title "Inactivation of protein tyrosine phosphatases by oltipraz and other cancer chemopreventive 1,2-dithiole-3-thiones" @default.
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• W2034256265 doi "https://doi.org/10.1016/j.bmc.2010.06.084" @default.
• W2034256265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3253851" @default.
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