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- W2034256521 abstract "Chronic intake of non-steroidal anti-inflammatory drugs (NSAIDs) increases significantly the risk of the development erosions, ulcers and bleeding within the alimentary tract, including the esophagus. Salivary protective factors, defining its viscous, gel-forming quality and its capacity to lubricate during swallowing, are well known for their protective potential within the oral cavity as well as esophageal and gastric mucosa. Furthermore, mastication, i.e. chewing of the tasteless parafilm results in 150%-300% increase in the flow of salivary volume as well as its protective factors in health and disease (Sarosiek et al. Gastroenterology, 110:675-81, 1996). Although the detrimental impact of naproxen on gastric mucus and mucin has been recently demonstrated (Jaworski et al. Dig. Dis. Sci., 50:357-65, 2005), its impact on protective quality of salivary secretion remains to be explored." @default.
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- W2034256521 date "2010-04-01" @default.
- W2034256521 modified "2023-10-16" @default.
- W2034256521 title "S1485: Injurious Impact of Naproxen on the Esophageal Mucosa in Humans Could Be At Least Partly Mediated Through Its Detrimental Effect on the Protective Quality of Salivary Secretion: Its Potential Clinical Implication" @default.
- W2034256521 doi "https://doi.org/10.1016/j.gie.2010.03.259" @default.
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