Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034256783> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W2034256783 endingPage "154" @default.
- W2034256783 startingPage "154" @default.
- W2034256783 abstract "The stringent guidelines for vitamin A intake during pregnancy have been justified by the identification of a single enzyme that activates the expression of specific target genes throughout the embryo. The enzyme CPY26 metabolizes retinoic acid (RA), an essential derivative of vitamin A. The uneven distribution of this vitamin along the central-body axis of the developing embryo is essential for normal development. Over- or under-dosage of vitamin A during pregnancy results in morphological defects ranging from cranio-facial, cardiac, lung and genito-urinary abnormalities to neurological abnormalities. The level of RA in the embryo is maintained by a delicate balance between RA synthesis and RA degradation. Hiroshi Hamada et al. [Genes Dev. (2001) 15, 213–225] and Martin Petkovich et al. [Genes Dev. (2001) 15, 226–240], performed genetic ablation of murine CYP26, which resulted in elevated RA levels in specific embryonic areas. The mutant mouse embryos were not viable – major defects including spina bifida, truncation of the posterior body and abnormalities of the kidney, brain and vertebrae were seen. CPY26 seems, therefore, to protect the developing embryo from the deleterious effects of excessive RA activity. S. de B." @default.
- W2034256783 created "2016-06-24" @default.
- W2034256783 creator A5001548815 @default.
- W2034256783 date "2001-03-01" @default.
- W2034256783 modified "2023-10-17" @default.
- W2034256783 title "‘A’ forming experience" @default.
- W2034256783 doi "https://doi.org/10.1016/s0968-0004(01)01809-6" @default.
- W2034256783 hasPublicationYear "2001" @default.
- W2034256783 type Work @default.
- W2034256783 sameAs 2034256783 @default.
- W2034256783 citedByCount "0" @default.
- W2034256783 crossrefType "journal-article" @default.
- W2034256783 hasAuthorship W2034256783A5001548815 @default.
- W2034256783 hasConcept C104317684 @default.
- W2034256783 hasConcept C126322002 @default.
- W2034256783 hasConcept C134018914 @default.
- W2034256783 hasConcept C196843134 @default.
- W2034256783 hasConcept C2776940978 @default.
- W2034256783 hasConcept C2778478650 @default.
- W2034256783 hasConcept C2779234561 @default.
- W2034256783 hasConcept C2781121885 @default.
- W2034256783 hasConcept C54355233 @default.
- W2034256783 hasConcept C71924100 @default.
- W2034256783 hasConcept C86803240 @default.
- W2034256783 hasConceptScore W2034256783C104317684 @default.
- W2034256783 hasConceptScore W2034256783C126322002 @default.
- W2034256783 hasConceptScore W2034256783C134018914 @default.
- W2034256783 hasConceptScore W2034256783C196843134 @default.
- W2034256783 hasConceptScore W2034256783C2776940978 @default.
- W2034256783 hasConceptScore W2034256783C2778478650 @default.
- W2034256783 hasConceptScore W2034256783C2779234561 @default.
- W2034256783 hasConceptScore W2034256783C2781121885 @default.
- W2034256783 hasConceptScore W2034256783C54355233 @default.
- W2034256783 hasConceptScore W2034256783C71924100 @default.
- W2034256783 hasConceptScore W2034256783C86803240 @default.
- W2034256783 hasIssue "3" @default.
- W2034256783 hasLocation W20342567831 @default.
- W2034256783 hasOpenAccess W2034256783 @default.
- W2034256783 hasPrimaryLocation W20342567831 @default.
- W2034256783 hasRelatedWork W10463414 @default.
- W2034256783 hasRelatedWork W11276075 @default.
- W2034256783 hasRelatedWork W12762272 @default.
- W2034256783 hasRelatedWork W12976067 @default.
- W2034256783 hasRelatedWork W23373974 @default.
- W2034256783 hasRelatedWork W24262415 @default.
- W2034256783 hasRelatedWork W4003918 @default.
- W2034256783 hasRelatedWork W5833580 @default.
- W2034256783 hasRelatedWork W11552398 @default.
- W2034256783 hasRelatedWork W24278397 @default.
- W2034256783 hasVolume "26" @default.
- W2034256783 isParatext "false" @default.
- W2034256783 isRetracted "false" @default.
- W2034256783 magId "2034256783" @default.
- W2034256783 workType "article" @default.