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- W2034258940 abstract "COPD is a disease with a multi-component pathophysiology in which inflammation plays a key role. An anti-inflammatory effect of salmeterol (S)/fluticasone propionate (FP) combination (SFC), as demonstrated in a number of biopsy studies, may be the mechanism by which it provides a potential survival benefit in COPD patients in the TORCH study. It is possible that the molecular synergy between S and FP shown in COPD results in enhanced anti-inflammatory in the airways. This may also contribute to the reduction in exacerbations and the increase in lung function seen in the TORCH study. Alternatively, SFC may prolong survival by impacting on systemic inflammation and disease co-morbidities in COPD." @default.
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- W2034258940 date "2008-01-01" @default.
- W2034258940 modified "2023-10-14" @default.
- W2034258940 title "Reflections on TORCH: Potential Mechanisms for the Survival Benefit of Salmeterol/Fluticasone Propionate in COPD Patients" @default.
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- W2034258940 doi "https://doi.org/10.1080/15412550802522924" @default.
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