FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034261032> ?p ?o ?g. }

• W2034261032 endingPage "e180" @default.
• W2034261032 startingPage "e180" @default.
• W2034261032 abstract "Relapsed or refractory Burkitt's lymphoma often has a poor prognosis in spite of intensive chemotherapy that induces apoptotic and/or necrotic death of lymphoma cells. Rapamycin (Rap) brings about autophagy, and could be another treatment. Further, anti-CD19-targeted liposomal delivery may enable Rap to kill lymphoma cells specifically. Rap was encapsulated by anionic liposome and conjugated with anti-CD19 antibody (CD19-GL-Rap) or anti-CD2 antibody (CD2-GL-Rap) as a control. A fluorescent probe Cy5.5 was also liposomized in the same way (CD19 or CD2-GL-Cy5.5) to examine the efficacy of anti-CD19-targeted liposomal delivery into CD19-positive Burkitt's lymphoma cell line, SKW6.4. CD19-GL-Cy5.5 was more effectively uptaken into SKW6.4 cells than CD2-GL-Cy5.5 in vitro. When the cells were inoculated subcutaneously into nonobese diabetic/severe combined immunodeficiency mice, intravenously administered CD19-GL-Cy5.5 made the subcutaneous tumor fluorescent, while CD2-GL-Cy5.5 did not. Further, CD19-GL-Rap had a greater cytocidal effect on not only SKW6.4 cells but also Burkitt's lymphoma cells derived from patients than CD2-GL-Rap in vitro. The specific toxicity of CD19-GL-Rap was cancelled by neutralizing anti-CD19 antibody. The survival period of mice treated with intravenous CD19-GL-Rap was significantly longer than that of mice treated with CD2-GL-Rap after intraperitoneal inoculation of SKW6.4 cells. Anti-CD19-targeted liposomal Rap could be a promising lymphoma cell-specific treatment inducing autophagic cell death." @default.
• W2034261032 created "2016-06-24" @default.
• W2034261032 creator A5008694549 @default.
• W2034261032 creator A5019037938 @default.
• W2034261032 creator A5019959563 @default.
• W2034261032 creator A5021158752 @default.
• W2034261032 creator A5022193625 @default.
• W2034261032 creator A5042912300 @default.
• W2034261032 creator A5044015982 @default.
• W2034261032 creator A5050710148 @default.
• W2034261032 creator A5052282410 @default.
• W2034261032 creator A5054498346 @default.
• W2034261032 creator A5056407210 @default.
• W2034261032 creator A5058051870 @default.
• W2034261032 creator A5058075352 @default.
• W2034261032 creator A5065771145 @default.
• W2034261032 creator A5074930047 @default.
• W2034261032 creator A5087008302 @default.
• W2034261032 date "2014-02-07" @default.
• W2034261032 modified "2023-10-10" @default.
• W2034261032 title "A novel strategy inducing autophagic cell death in Burkitt's lymphoma cells with anti-CD19-targeted liposomal rapamycin" @default.
• W2034261032 cites W1903762140 @default.
• W2034261032 cites W1965912776 @default.
• W2034261032 cites W1972078736 @default.
• W2034261032 cites W1988184140 @default.
• W2034261032 cites W2002211884 @default.
• W2034261032 cites W2039149747 @default.
• W2034261032 cites W2060352037 @default.
• W2034261032 cites W2125756572 @default.
• W2034261032 cites W2129106215 @default.
• W2034261032 cites W2140793516 @default.
• W2034261032 cites W2143358417 @default.
• W2034261032 cites W2152645133 @default.
• W2034261032 cites W2154309902 @default.
• W2034261032 cites W2168397233 @default.
• W2034261032 doi "https://doi.org/10.1038/bcj.2014.2" @default.
• W2034261032 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3944660" @default.
• W2034261032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24510029" @default.
• W2034261032 hasPublicationYear "2014" @default.
• W2034261032 type Work @default.
• W2034261032 sameAs 2034261032 @default.
• W2034261032 citedByCount "10" @default.
• W2034261032 countsByYear W20342610322015 @default.
• W2034261032 countsByYear W20342610322016 @default.
• W2034261032 countsByYear W20342610322018 @default.
• W2034261032 countsByYear W20342610322019 @default.
• W2034261032 countsByYear W20342610322022 @default.
• W2034261032 countsByYear W20342610322023 @default.
• W2034261032 crossrefType "journal-article" @default.
• W2034261032 hasAuthorship W2034261032A5008694549 @default.
• W2034261032 hasAuthorship W2034261032A5019037938 @default.
• W2034261032 hasAuthorship W2034261032A5019959563 @default.
• W2034261032 hasAuthorship W2034261032A5021158752 @default.
• W2034261032 hasAuthorship W2034261032A5022193625 @default.
• W2034261032 hasAuthorship W2034261032A5042912300 @default.
• W2034261032 hasAuthorship W2034261032A5044015982 @default.
• W2034261032 hasAuthorship W2034261032A5050710148 @default.
• W2034261032 hasAuthorship W2034261032A5052282410 @default.
• W2034261032 hasAuthorship W2034261032A5054498346 @default.
• W2034261032 hasAuthorship W2034261032A5056407210 @default.
• W2034261032 hasAuthorship W2034261032A5058051870 @default.
• W2034261032 hasAuthorship W2034261032A5058075352 @default.
• W2034261032 hasAuthorship W2034261032A5065771145 @default.
• W2034261032 hasAuthorship W2034261032A5074930047 @default.
• W2034261032 hasAuthorship W2034261032A5087008302 @default.
• W2034261032 hasBestOaLocation W20342610321 @default.
• W2034261032 hasConcept C159654299 @default.
• W2034261032 hasConcept C203014093 @default.
• W2034261032 hasConcept C2778913318 @default.
• W2034261032 hasConcept C2778957590 @default.
• W2034261032 hasConcept C2779338263 @default.
• W2034261032 hasConcept C502942594 @default.
• W2034261032 hasConcept C71924100 @default.
• W2034261032 hasConcept C86803240 @default.
• W2034261032 hasConceptScore W2034261032C159654299 @default.
• W2034261032 hasConceptScore W2034261032C203014093 @default.
• W2034261032 hasConceptScore W2034261032C2778913318 @default.
• W2034261032 hasConceptScore W2034261032C2778957590 @default.
• W2034261032 hasConceptScore W2034261032C2779338263 @default.
• W2034261032 hasConceptScore W2034261032C502942594 @default.
• W2034261032 hasConceptScore W2034261032C71924100 @default.
• W2034261032 hasConceptScore W2034261032C86803240 @default.
• W2034261032 hasIssue "2" @default.
• W2034261032 hasLocation W20342610321 @default.
• W2034261032 hasLocation W20342610322 @default.
• W2034261032 hasLocation W20342610323 @default.
• W2034261032 hasLocation W20342610324 @default.
• W2034261032 hasOpenAccess W2034261032 @default.
• W2034261032 hasPrimaryLocation W20342610321 @default.
• W2034261032 hasRelatedWork W1968589358 @default.
• W2034261032 hasRelatedWork W2041230744 @default.
• W2034261032 hasRelatedWork W2156365530 @default.
• W2034261032 hasRelatedWork W2189404152 @default.
• W2034261032 hasRelatedWork W2261314500 @default.
• W2034261032 hasRelatedWork W2394632511 @default.
• W2034261032 hasRelatedWork W2433456738 @default.
• W2034261032 hasRelatedWork W2472045387 @default.
• W2034261032 hasRelatedWork W2563458970 @default.

• next