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- W2034261288 abstract "Human papillomavirus (HPV) L1 and L2 capsid protein expression is restricted to the granular layer of infected, stratified epithelia and is regulated at least partly at post-transcriptional levels. For HPV16, a 79 nt late regulatory element (LRE) is involved in this control. Using W12 cells as a model for HPV16-infected differentiating cervical epithelial cells we show that HuR, a key cellular protein that controls mRNA stability, binds the LRE most efficiently in nuclear and cytoplasmic extracts of differentiated cells. Further, HuR binds the 3′ U-rich portion of the LRE directly in vitro. Overexpression of HuR in undifferentiated W12 cells results in an increase in L1 mRNA and protein levels while siRNA knock-down of HuR in differentiated W12 cells depletes L1 expression. In differentiated cervical epithelial cells HuR may bind and stabilise L1 mRNAs aiding translation of L1 protein." @default.
- W2034261288 created "2016-06-24" @default.
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- W2034261288 date "2009-01-01" @default.
- W2034261288 modified "2023-10-18" @default.
- W2034261288 title "The RNA stability regulator HuR regulates L1 protein expression in vivo in differentiating cervical epithelial cells" @default.
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- W2034261288 doi "https://doi.org/10.1016/j.virol.2008.10.003" @default.
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