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- W2034264974 abstract "Gap junctions are specialized cell-to-cell contacts that provide direct intercellular communication. In the central nervous system (CNS), gap junction coupling occurs between both neurons and glial cells. One of the most abundant gap junction proteins in the CNS is connexin43 (Cx43). The functional syncytium formed by astrocytes via Cx43 gap junction intercellular communication has, for example, been implicated in maintaining the homeostasis of the extracellular milieu of neurons. In particular, astrocytes are involved in the spatial buffering of many ions, signalling molecules and energy sources. In this review, the role of Cx43 following CNS injury is examined by combining evidence surrounding the response of Cx43 to CNS injury and the effects of Cx43 gap junction blockade on neuronal survival in various models of injury. Combined evidence suggests that transient blockade targeting the window of initial Cx43 upregulation observed following injury is potentially therapeutic." @default.
- W2034264974 created "2016-06-24" @default.
- W2034264974 creator A5046539019 @default.
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- W2034264974 creator A5083983181 @default.
- W2034264974 date "2010-10-01" @default.
- W2034264974 modified "2023-10-14" @default.
- W2034264974 title "Role of connexin43 in central nervous system injury" @default.
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- W2034264974 doi "https://doi.org/10.1016/j.expneurol.2010.07.014" @default.
- W2034264974 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20655909" @default.
- W2034264974 hasPublicationYear "2010" @default.
- W2034264974 type Work @default.