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- W2034265711 abstract "Myocardial tissue engineering offers a novel technology to improve or regenerate cardiac functions using a combination of cells, biomaterials and engineering strategies. Inspired by low-resistance pathways for electrical signal propagation in the native heart tissue, electrically conductive nanofibrous scaffolds composed of melanin, poly(l-lactide-co-ε-caprolactone) and gelatin were fabricated to provide electrophysiological cues to cardiac myocytes and mimic the native myocardial environment. Our results show that by increasing the concentration of melanin to 40% within the composite, the fiber diameters reduced to 153 ± 30 nm, modulus decreased to 7.1 ± 0.6 MPa, and conductance increased to 259.51 ± 187.60 μS cm-1. Results of cell proliferation and immunostaining analysis of human cardiac myocytes demonstrated that the conductive nanofibers containing 10% melanin promote cell interaction with expression of cardiac-specific proteins compared to other scaffolds. Electrical stimulation through the scaffolds showed enhanced cell proliferation and the expression of connexin-43, signifying the potential of using melanin containing nanofibers as a suitable cardiac patch for the regeneration of infarct myocardium." @default.
- W2034265711 created "2016-06-24" @default.
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- W2034265711 date "2013-01-01" @default.
- W2034265711 modified "2023-10-07" @default.
- W2034265711 title "Biocompatibility evaluation of electrically conductive nanofibrous scaffolds for cardiac tissue engineering" @default.
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- W2034265711 doi "https://doi.org/10.1039/c3tb00151b" @default.
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