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• W2034266432 endingPage "74" @default.
• W2034266432 startingPage "53" @default.
• W2034266432 abstract "Palatogenesis is a complex developmental process that requires two main events: elevation and then fusion of the palatal shelves. There remains controversy concerning the mechanism(s) responsible for palatal shelf elevation, it being proposed that an intrinsic shelf elevation force might be produced either by the generation of a turgor pressure following hydration of the extracellular matrix via its glycoconjugate molecules or by proliferation, migration and/or contraction of the palatal shelf mesenchymal cells. Recent evidence indicates that the shelf elevation force is related to the presence of hyaluronan in the extracellular matrix, to an as yet unknown molecule that is packaged in the mesenchymal cells' Golgi complex, and to CD44 receptor functioning. For fusion of the palatal shelves to occur, the breakdown of the midline epithelial seam relates to apoptosis and redifferentiation of the epithelial cells and this appears to be signalled by the synthesis of type IX collagen just prior to the breakdown of the basement membrane around the midline epithelial seam. The events associated with palatogenesis are controlled by the palatal shelf mesenchyme, under the influence of a variety of homeobox genes and transcription factors and and of several growth factors (particularly TGF-?s)." @default.
• W2034266432 created "2016-06-24" @default.
• W2034266432 creator A5073986290 @default.
• W2034266432 date "2003-01-01" @default.
• W2034266432 modified "2023-09-26" @default.
• W2034266432 title "The development of the palate - a brief review" @default.
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