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- W2034267913 abstract "The gut peptide ghrelin is expressed within neurons of the hypothalamus. Using a hypothalamic cell line, mHypoE-38 neurons, the effect of insulin on preproghrelin gene expression was assayed. These cells contain neuron-specific markers, preproghrelin and the insulin receptor. We determined that insulin has direct effects on preproghrelin gene expression. Insulin (10 nM) stimulated protein kinase B (Akt) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) phosphorylation from 5 to 60 min and 5 min, respectively, and led to repression of preproghrelin gene expression at 2 h. Pharmacological inhibitors to phosphoinositide-3-kinase (PI3-K; LY294002) and MEK (PD98059) demonstrated that basal ghrelin gene expression is regulated by the PI3-K pathway and requires the mitogen-activated protein kinase pathway for insulin-stimulated preproghrelin repression. These results demonstrate that insulin has a direct effect on hypothalamic neurons to decrease preproghrelin gene expression through classic insulin pathways." @default.
- W2034267913 created "2016-06-24" @default.
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- W2034267913 date "2009-01-01" @default.
- W2034267913 modified "2023-09-25" @default.
- W2034267913 title "Hypothalamic Preproghrelin Gene Expression Is Repressed by Insulin via Both PI3-K/Akt and ERK1/2 MAPK Pathways in Immortalized, Hypothalamic Neurons" @default.
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- W2034267913 doi "https://doi.org/10.1159/000167698" @default.
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