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• W2034268677 abstract "A murine monoclonal antibody, mAb 8523, raised against whole human pro-monocytic U937 cells recognizes an 18 kDa antigen in human neutrophils (PMN), as determined by immunoprecipitation and by immunodetection on Western blots of SDS-PAGE of PMN membrane fractions. That is 18 kDa antigen corresponds to the phagocyte peripheral benzodiazepine receptor (PBZDR) is evidenced by its co-migration with the 18 kDa covalently labeled PBZDR, detected by autoradiography, and their co-modulation upon phorbol-myristate-acetate activation of PMN. Purified mAb 8523 (IgG2b) is able to dose-dependently and specifically stimulate both the basal and the FMLP-induced oxidative burst of intact human PMN, assessed by luminol-amplified chemiluminescence. This property of the first described monoclonal antibody against PBZDR supports the implication of this receptor in NADPH-oxidase activation and consequently in phagocyte-dependent host defense mechanisms." @default.
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• W2034268677 date "1991-05-01" @default.
• W2034268677 modified "2023-09-25" @default.
• W2034268677 title "A monoclonal antibody against peripheral benzodiazepine receptor activates the human neutrophil NADPH-oxidase" @default.
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• W2034268677 doi "https://doi.org/10.1016/0006-291x(91)90468-m" @default.
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