FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034269975> ?p ?o ?g. }

• W2034269975 endingPage "1026" @default.
• W2034269975 startingPage "1015" @default.
• W2034269975 abstract "Complement (C) is an important component of innate immunity, and was also shown recently to participate in induction of acquired B cell humoral immunity. In this study, we present evidence that C also participates in acquired T cell immunity. We found that C was involved in early events of the efferent elicitation phase of contact sensitivity (CS), and delayed-type hypersensitivity (DTH). Thus, CS and DTH were inhibited by administration of a C-blocker, soluble recombinant C receptor-1 (sCR1), when given 30 min before, but not 3 h after local antigen challenge. Among C components, local C5 were thought crucial to elicitation of CS, since local administration of anti-C5 monoclonal antibodies or locally injected C-depleting cobra venom factor also inhibited CS and DTH. These findings were consistent with our previous finding of the importance of C5 for CS elicitation, using congenitally C5-deficient mice. To dissect the mechanism of C dependence in CS, we demonstrated that locally increased early macrophage chemotactic activity (probably C5a) in evolving CS skin extracts, as well as late elaboration of IFN-γ, were both inhibited by anti-C treatment. In addition, histological analysis showed that leukocyte recruitment into CS ear sites was similarly C-dependent. Furthermore, an initiating role of B cell–derived C-fixing immunoglobulin was suggested by demonstration of impaired CS responses in B cell–deficient mice. In summary, these results suggest that C was activated locally, perhaps via a B cell product, in an important early component of the stepwise events necessary to elicit CS, leading to local production of C5-dependent macrophage chemotactic activity and later IFN-γ, and subsequently leading to cell infiltration, for development of T cell–dependent CS." @default.
• W2034269975 created "2016-06-24" @default.
• W2034269975 creator A5010057342 @default.
• W2034269975 creator A5013076379 @default.
• W2034269975 creator A5031486826 @default.
• W2034269975 creator A5052511743 @default.
• W2034269975 creator A5059837134 @default.
• W2034269975 creator A5082465033 @default.
• W2034269975 date "1997-10-06" @default.
• W2034269975 modified "2023-10-17" @default.
• W2034269975 title "Required Early Complement Activation in Contact Sensitivity with Generation of Local C5-dependent Chemotactic Activity, and Late T Cell Interferon γ: A Possible Initiating Role of B Cells" @default.
• W2034269975 cites W110411724 @default.
• W2034269975 cites W1479855875 @default.
• W2034269975 cites W1500996664 @default.
• W2034269975 cites W1531027674 @default.
• W2034269975 cites W1543907558 @default.
• W2034269975 cites W1545547564 @default.
• W2034269975 cites W1547290744 @default.
• W2034269975 cites W1570674580 @default.
• W2034269975 cites W1582917949 @default.
• W2034269975 cites W1640692612 @default.
• W2034269975 cites W1663851119 @default.
• W2034269975 cites W1810297567 @default.
• W2034269975 cites W1914932411 @default.
• W2034269975 cites W1929967830 @default.
• W2034269975 cites W1942920640 @default.
• W2034269975 cites W1979514172 @default.
• W2034269975 cites W1982196736 @default.
• W2034269975 cites W1987200598 @default.
• W2034269975 cites W1990463170 @default.
• W2034269975 cites W1991464867 @default.
• W2034269975 cites W1995219446 @default.
• W2034269975 cites W2008139210 @default.
• W2034269975 cites W2020521060 @default.
• W2034269975 cites W2021648547 @default.
• W2034269975 cites W2026826212 @default.
• W2034269975 cites W2032348735 @default.
• W2034269975 cites W2037796326 @default.
• W2034269975 cites W2038046316 @default.
• W2034269975 cites W2038195232 @default.
• W2034269975 cites W2038384507 @default.
• W2034269975 cites W2056824071 @default.
• W2034269975 cites W2056876225 @default.
• W2034269975 cites W2059502318 @default.
• W2034269975 cites W2060179486 @default.
• W2034269975 cites W2062981413 @default.
• W2034269975 cites W2067146840 @default.
• W2034269975 cites W2071177681 @default.
• W2034269975 cites W2074296560 @default.
• W2034269975 cites W2083657978 @default.
• W2034269975 cites W2088441239 @default.
• W2034269975 cites W2090327255 @default.
• W2034269975 cites W2095218693 @default.
• W2034269975 cites W2102291237 @default.
• W2034269975 cites W2112249032 @default.
• W2034269975 cites W2119337299 @default.
• W2034269975 cites W2126600660 @default.
• W2034269975 cites W2132173299 @default.
• W2034269975 cites W2148726934 @default.
• W2034269975 cites W2158888311 @default.
• W2034269975 cites W2159134769 @default.
• W2034269975 cites W2323376528 @default.
• W2034269975 cites W2405011991 @default.
• W2034269975 cites W2440085321 @default.
• W2034269975 cites W296098327 @default.
• W2034269975 cites W4313308945 @default.
• W2034269975 doi "https://doi.org/10.1084/jem.186.7.1015" @default.
• W2034269975 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2199060" @default.
• W2034269975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9314551" @default.
• W2034269975 hasPublicationYear "1997" @default.
• W2034269975 type Work @default.
• W2034269975 sameAs 2034269975 @default.
• W2034269975 citedByCount "79" @default.
• W2034269975 countsByYear W20342699752012 @default.
• W2034269975 countsByYear W20342699752013 @default.
• W2034269975 countsByYear W20342699752014 @default.
• W2034269975 countsByYear W20342699752015 @default.
• W2034269975 countsByYear W20342699752016 @default.
• W2034269975 countsByYear W20342699752018 @default.
• W2034269975 countsByYear W20342699752019 @default.
• W2034269975 countsByYear W20342699752021 @default.
• W2034269975 countsByYear W20342699752022 @default.
• W2034269975 crossrefType "journal-article" @default.
• W2034269975 hasAuthorship W2034269975A5010057342 @default.
• W2034269975 hasAuthorship W2034269975A5013076379 @default.
• W2034269975 hasAuthorship W2034269975A5031486826 @default.
• W2034269975 hasAuthorship W2034269975A5052511743 @default.
• W2034269975 hasAuthorship W2034269975A5059837134 @default.
• W2034269975 hasAuthorship W2034269975A5082465033 @default.
• W2034269975 hasBestOaLocation W20342699751 @default.
• W2034269975 hasConcept C111684460 @default.
• W2034269975 hasConcept C153911025 @default.
• W2034269975 hasConcept C159654299 @default.
• W2034269975 hasConcept C170493617 @default.
• W2034269975 hasConcept C203014093 @default.
• W2034269975 hasConcept C2779341262 @default.
• W2034269975 hasConcept C2779499704 @default.
• W2034269975 hasConcept C54166955 @default.

• next