Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034271451> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2034271451 endingPage "1167" @default.
- W2034271451 startingPage "1159" @default.
- W2034271451 abstract "Nearly 150 different enzymatically modified forms of the four canonical residues in RNA have been identified. For instance, enzymes of the ADAR (adenosine deaminase acting on RNA) family convert adenosine residues into inosine in cellular dsRNAs. Recent findings show that DNA endonuclease V enzymes have undergone an evolutionary transition from cleaving 3′ to deoxyinosine in DNA and ssDNA to cleaving 3′ to inosine in dsRNA and ssRNA in humans. Recent work on dsRNA-binding domains of ADARs and other proteins also shows that a degree of sequence specificity is achieved by direct readout in the minor groove. However, the level of sequence specificity observed is much less than that of DNA major groove-binding helix–turn–helix proteins. We suggest that the evolution of DNA-binding proteins following the RNA to DNA genome transition represents the major advantage that DNA genomes have over RNA genomes. We propose that a hypothetical RNA modification, a RRAR (ribose reductase acting on genomic dsRNA) produced the first stretches of DNA in RNA genomes. We discuss why this is the most satisfactory explanation for the origin of DNA. The evolution of this RNA modification and later steps to DNA genomes are likely to have been driven by cellular genome co-evolution with viruses and intragenomic parasites. RNA modifications continue to be involved in host–virus conflicts; in vertebrates, edited cellular dsRNAs with inosine–uracil base pairs appear to be recognized as self RNA and to suppress activation of innate immune sensors that detect viral dsRNA." @default.
- W2034271451 created "2016-06-24" @default.
- W2034271451 creator A5030542209 @default.
- W2034271451 creator A5050487031 @default.
- W2034271451 date "2014-08-01" @default.
- W2034271451 modified "2023-09-27" @default.
- W2034271451 title "Conflict RNA modification, host–parasite co-evolution, and the origins of DNA and DNA-binding proteins1" @default.
- W2034271451 cites W1510015995 @default.
- W2034271451 cites W1967663492 @default.
- W2034271451 cites W1973861730 @default.
- W2034271451 cites W1973960846 @default.
- W2034271451 cites W1975475128 @default.
- W2034271451 cites W1976209715 @default.
- W2034271451 cites W1982749428 @default.
- W2034271451 cites W1986586522 @default.
- W2034271451 cites W1999361121 @default.
- W2034271451 cites W2010736443 @default.
- W2034271451 cites W2022211160 @default.
- W2034271451 cites W2025980739 @default.
- W2034271451 cites W2026598193 @default.
- W2034271451 cites W2026690931 @default.
- W2034271451 cites W2030887477 @default.
- W2034271451 cites W2032293502 @default.
- W2034271451 cites W2038679427 @default.
- W2034271451 cites W2040681799 @default.
- W2034271451 cites W2042433863 @default.
- W2034271451 cites W2055145209 @default.
- W2034271451 cites W2080847523 @default.
- W2034271451 cites W2095162524 @default.
- W2034271451 cites W2098645655 @default.
- W2034271451 cites W2106096530 @default.
- W2034271451 cites W2111565312 @default.
- W2034271451 cites W2113984622 @default.
- W2034271451 cites W2120224547 @default.
- W2034271451 cites W2123217482 @default.
- W2034271451 cites W2134259738 @default.
- W2034271451 cites W2145848565 @default.
- W2034271451 cites W2149573719 @default.
- W2034271451 cites W2155139766 @default.
- W2034271451 cites W2161603653 @default.
- W2034271451 cites W2390421705 @default.
- W2034271451 doi "https://doi.org/10.1042/bst20140147" @default.
- W2034271451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25110019" @default.
- W2034271451 hasPublicationYear "2014" @default.
- W2034271451 type Work @default.
- W2034271451 sameAs 2034271451 @default.
- W2034271451 citedByCount "4" @default.
- W2034271451 countsByYear W20342714512014 @default.
- W2034271451 countsByYear W20342714512017 @default.
- W2034271451 countsByYear W20342714512018 @default.
- W2034271451 countsByYear W20342714512019 @default.
- W2034271451 crossrefType "journal-article" @default.
- W2034271451 hasAuthorship W2034271451A5030542209 @default.
- W2034271451 hasAuthorship W2034271451A5050487031 @default.
- W2034271451 hasBestOaLocation W20342714512 @default.
- W2034271451 hasConcept C104317684 @default.
- W2034271451 hasConcept C141231307 @default.
- W2034271451 hasConcept C166703698 @default.
- W2034271451 hasConcept C21786251 @default.
- W2034271451 hasConcept C2191507 @default.
- W2034271451 hasConcept C2778323267 @default.
- W2034271451 hasConcept C54355233 @default.
- W2034271451 hasConcept C552990157 @default.
- W2034271451 hasConcept C67705224 @default.
- W2034271451 hasConcept C86803240 @default.
- W2034271451 hasConceptScore W2034271451C104317684 @default.
- W2034271451 hasConceptScore W2034271451C141231307 @default.
- W2034271451 hasConceptScore W2034271451C166703698 @default.
- W2034271451 hasConceptScore W2034271451C21786251 @default.
- W2034271451 hasConceptScore W2034271451C2191507 @default.
- W2034271451 hasConceptScore W2034271451C2778323267 @default.
- W2034271451 hasConceptScore W2034271451C54355233 @default.
- W2034271451 hasConceptScore W2034271451C552990157 @default.
- W2034271451 hasConceptScore W2034271451C67705224 @default.
- W2034271451 hasConceptScore W2034271451C86803240 @default.
- W2034271451 hasIssue "4" @default.
- W2034271451 hasLocation W20342714511 @default.
- W2034271451 hasLocation W20342714512 @default.
- W2034271451 hasLocation W20342714513 @default.
- W2034271451 hasOpenAccess W2034271451 @default.
- W2034271451 hasPrimaryLocation W20342714511 @default.
- W2034271451 hasRelatedWork W2002695739 @default.
- W2034271451 hasRelatedWork W2051453397 @default.
- W2034271451 hasRelatedWork W2115221577 @default.
- W2034271451 hasRelatedWork W2192293591 @default.
- W2034271451 hasRelatedWork W2337061448 @default.
- W2034271451 hasRelatedWork W2601687993 @default.
- W2034271451 hasRelatedWork W3045609220 @default.
- W2034271451 hasRelatedWork W3170636902 @default.
- W2034271451 hasRelatedWork W4286489309 @default.
- W2034271451 hasRelatedWork W94428214 @default.
- W2034271451 hasVolume "42" @default.
- W2034271451 isParatext "false" @default.
- W2034271451 isRetracted "false" @default.
- W2034271451 magId "2034271451" @default.
- W2034271451 workType "article" @default.