Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034271909> ?p ?o ?g. }
- W2034271909 endingPage "e9859" @default.
- W2034271909 startingPage "e9859" @default.
- W2034271909 abstract "Although World Health Organization guidelines recommend clinical judgment and chest radiography for diagnosing tuberculosis in HIV-infected adults with unexplained cough and negative sputum smears for acid-fast bacilli, the diagnostic performance of this approach is unknown. Therefore, we sought to assess the accuracy of symptoms, physical signs, and radiographic findings for diagnosing tuberculosis in this population in a low-income country with a high incidence of tuberculosis.We performed a cross-sectional study enrolling consecutive HIV-infected inpatients with unexplained cough and negative sputum smears for acid-fast bacilli at Mulago Hospital in Kampala, Uganda. Trained medical officers prospectively collected data on standard symptoms and signs of systemic respiratory illness, and two radiologists interpreted chest radiographs in a standardized fashion. We calculated positive- and negative-likelihood ratios of these factors for diagnosing pulmonary tuberculosis (defined when mycobacterial cultures of sputum or bronchoalveolar lavage fluid were positive). We used both conventional and novel regression techniques to develop multivariable prediction models for pulmonary tuberculosis.Among 202 enrolled HIV-infected adults with negative sputum smears for acid-fast bacilli, 72 (36%) had culture-positive pulmonary tuberculosis. No single factor, including respiratory symptoms, physical findings, CD4+ T-cell count, or chest radiographic abnormalities, substantially increased or decreased the likelihood of pulmonary tuberculosis. After exhaustive testing, we were also unable to identify any combination of factors which reliably predicted bacteriologically confirmed tuberculosis.Clinical and radiographic criteria did not help diagnose smear-negative pulmonary tuberculosis among HIV-infected patients with unexplained cough in a low-income setting. Enhanced diagnostic methods for smear-negative tuberculosis are urgently needed." @default.
- W2034271909 created "2016-06-24" @default.
- W2034271909 creator A5004781847 @default.
- W2034271909 creator A5012398850 @default.
- W2034271909 creator A5025423844 @default.
- W2034271909 creator A5029675144 @default.
- W2034271909 creator A5034566915 @default.
- W2034271909 creator A5035790758 @default.
- W2034271909 creator A5040140770 @default.
- W2034271909 creator A5045600642 @default.
- W2034271909 creator A5047981015 @default.
- W2034271909 creator A5073273696 @default.
- W2034271909 creator A5075140316 @default.
- W2034271909 creator A5081991257 @default.
- W2034271909 date "2010-03-26" @default.
- W2034271909 modified "2023-10-05" @default.
- W2034271909 title "Clinical and Radiographic Factors Do Not Accurately Diagnose Smear-Negative Tuberculosis in HIV-infected Inpatients in Uganda: A Cross-Sectional Study" @default.
- W2034271909 cites W109542601 @default.
- W2034271909 cites W115935013 @default.
- W2034271909 cites W1485769 @default.
- W2034271909 cites W1688345636 @default.
- W2034271909 cites W171177021 @default.
- W2034271909 cites W1728638204 @default.
- W2034271909 cites W1972679953 @default.
- W2034271909 cites W1982426229 @default.
- W2034271909 cites W1985158540 @default.
- W2034271909 cites W1988516425 @default.
- W2034271909 cites W2001906551 @default.
- W2034271909 cites W2005016568 @default.
- W2034271909 cites W2006783986 @default.
- W2034271909 cites W2017460912 @default.
- W2034271909 cites W2017483161 @default.
- W2034271909 cites W2028138906 @default.
- W2034271909 cites W2031380064 @default.
- W2034271909 cites W2032833657 @default.
- W2034271909 cites W2088125673 @default.
- W2034271909 cites W2092369971 @default.
- W2034271909 cites W2098091079 @default.
- W2034271909 cites W2102104299 @default.
- W2034271909 cites W2106754904 @default.
- W2034271909 cites W2108049621 @default.
- W2034271909 cites W2108507904 @default.
- W2034271909 cites W2111719904 @default.
- W2034271909 cites W2118179479 @default.
- W2034271909 cites W2121514893 @default.
- W2034271909 cites W2127802024 @default.
- W2034271909 cites W2129925362 @default.
- W2034271909 cites W2130373985 @default.
- W2034271909 cites W2136124840 @default.
- W2034271909 cites W2139257281 @default.
- W2034271909 cites W2153812316 @default.
- W2034271909 cites W2155019748 @default.
- W2034271909 cites W2157201941 @default.
- W2034271909 cites W2162750699 @default.
- W2034271909 cites W2276237089 @default.
- W2034271909 cites W2329818719 @default.
- W2034271909 cites W2413881059 @default.
- W2034271909 cites W2987628802 @default.
- W2034271909 cites W3519884 @default.
- W2034271909 doi "https://doi.org/10.1371/journal.pone.0009859" @default.
- W2034271909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2845634" @default.
- W2034271909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20361038" @default.
- W2034271909 hasPublicationYear "2010" @default.
- W2034271909 type Work @default.
- W2034271909 sameAs 2034271909 @default.
- W2034271909 citedByCount "44" @default.
- W2034271909 countsByYear W20342719092012 @default.
- W2034271909 countsByYear W20342719092013 @default.
- W2034271909 countsByYear W20342719092014 @default.
- W2034271909 countsByYear W20342719092015 @default.
- W2034271909 countsByYear W20342719092016 @default.
- W2034271909 countsByYear W20342719092017 @default.
- W2034271909 countsByYear W20342719092018 @default.
- W2034271909 countsByYear W20342719092019 @default.
- W2034271909 countsByYear W20342719092020 @default.
- W2034271909 countsByYear W20342719092021 @default.
- W2034271909 countsByYear W20342719092022 @default.
- W2034271909 countsByYear W20342719092023 @default.
- W2034271909 crossrefType "journal-article" @default.
- W2034271909 hasAuthorship W2034271909A5004781847 @default.
- W2034271909 hasAuthorship W2034271909A5012398850 @default.
- W2034271909 hasAuthorship W2034271909A5025423844 @default.
- W2034271909 hasAuthorship W2034271909A5029675144 @default.
- W2034271909 hasAuthorship W2034271909A5034566915 @default.
- W2034271909 hasAuthorship W2034271909A5035790758 @default.
- W2034271909 hasAuthorship W2034271909A5040140770 @default.
- W2034271909 hasAuthorship W2034271909A5045600642 @default.
- W2034271909 hasAuthorship W2034271909A5047981015 @default.
- W2034271909 hasAuthorship W2034271909A5073273696 @default.
- W2034271909 hasAuthorship W2034271909A5075140316 @default.
- W2034271909 hasAuthorship W2034271909A5081991257 @default.
- W2034271909 hasBestOaLocation W20342719091 @default.
- W2034271909 hasConcept C120665830 @default.
- W2034271909 hasConcept C121332964 @default.
- W2034271909 hasConcept C126322002 @default.
- W2034271909 hasConcept C142052008 @default.
- W2034271909 hasConcept C142724271 @default.
- W2034271909 hasConcept C2776301714 @default.