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• W2034273529 endingPage "e1000636" @default.
• W2034273529 startingPage "e1000636" @default.
• W2034273529 abstract "Severe Acute Respiratory Syndrome caused substantial morbidity and mortality during the 2002-2003 epidemic. Many of the features of the human disease are duplicated in BALB/c mice infected with a mouse-adapted version of the virus (MA15), which develop respiratory disease with high morbidity and mortality. Here, we show that severe disease is correlated with slow kinetics of virus clearance and delayed activation and transit of respiratory dendritic cells (rDC) to the draining lymph nodes (DLN) with a consequent deficient virus-specific T cell response. All of these defects are corrected when mice are treated with liposomes containing clodronate, which deplete alveolar macrophages (AM). Inhibitory AMs are believed to prevent the development of immune responses to environmental antigens and allergic responses by interacting with lung dendritic cells and T cells. The inhibitory effects of AM can also be nullified if mice or AMs are pretreated with poly I:C, which directly activate AMs and rDCs through toll-like receptors 3 (TLR3). Further, adoptive transfer of activated but not resting bone marrow-derived dendritic cells (BMDC) protect mice from lethal MA15 infection. These results may be relevant for SARS in humans, which is also characterized by prolonged virus persistence and delayed development of a SARS-CoV-specific immune response in individuals with severe disease." @default.
• W2034273529 created "2016-06-24" @default.
• W2034273529 creator A5023693252 @default.
• W2034273529 creator A5051474892 @default.
• W2034273529 creator A5077063785 @default.
• W2034273529 creator A5079003683 @default.
• W2034273529 date "2009-10-23" @default.
• W2034273529 modified "2023-10-14" @default.
• W2034273529 title "Evasion by Stealth: Inefficient Immune Activation Underlies Poor T Cell Response and Severe Disease in SARS-CoV-Infected Mice" @default.
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• W2034273529 doi "https://doi.org/10.1371/journal.ppat.1000636" @default.
• W2034273529 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2762542" @default.
• W2034273529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19851468" @default.
• W2034273529 hasPublicationYear "2009" @default.
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