FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034273648> ?p ?o ?g. }

• W2034273648 endingPage "280" @default.
• W2034273648 startingPage "269" @default.
• W2034273648 abstract "Analysis of the mechanisms underlying cardiac excitability can be facilitated greatly by mutations that disrupt ion channels and receptors involved in this excitability. With an extensive repertoire of such mutations, Drosophila provides the best available genetic model for these studies. However, the use of Drosophila for this purpose has been severely handicapped by lack of a suitable preparation of heart and a complete lack of knowledge about the ionic currents that underlie its excitability. We describe a simple preparation to measure heartbeat in Drosophila. This preparation was used to ask if heartbeat in Drosophila is myogenic in origin, and to determine the types of ion channels involved in influencing the heart rate. Tetrodotoxin, even at a high concentration of 40 microM, did not affect heart rate, indicating that heartbeat may be myogenic in origin and that it may not be determined by Na+ channels. Heart rate was affected by PN200-110, verapamil, and diltiazem, which block vertebrate L-type Ca2+ channels. Thus, L-type channels, which contribute to the prolonged plateau of action potentials in vertebrate heart, may play a role in Drosophila cardiac excitability. It also suggests that Drosophila heart is subject to a similar intervention by organic Ca2+ channel blockers as the vertebrate heart. A role for K+ currents in the function of Drosophila heart was suggested by an effect of tetraethylammonium, which blocks all the four identified K+ currents in the larval body wall muscles, and quinidine, which blocks the delayed rectifier K+ current in these muscles. The preparation described here also provides an extremely simple method for identifying mutations that affect heart rate. Such mutations and pharmacological agents will be very useful for analyzing molecular components of cardiac excitability in Drosophila." @default.
• W2034273648 created "2016-06-24" @default.
• W2034273648 creator A5041890940 @default.
• W2034273648 creator A5086368037 @default.
• W2034273648 date "1995-11-01" @default.
• W2034273648 modified "2023-10-18" @default.
• W2034273648 title "Pharmacological analysis of heartbeat inDrosophila" @default.
• W2034273648 cites W106985358 @default.
• W2034273648 cites W1597030777 @default.
• W2034273648 cites W1608420792 @default.
• W2034273648 cites W1622707836 @default.
• W2034273648 cites W1931531285 @default.
• W2034273648 cites W1953050875 @default.
• W2034273648 cites W196651220 @default.
• W2034273648 cites W1967297467 @default.
• W2034273648 cites W1972188808 @default.
• W2034273648 cites W1972882396 @default.
• W2034273648 cites W1974997331 @default.
• W2034273648 cites W1977912923 @default.
• W2034273648 cites W1981324262 @default.
• W2034273648 cites W1983423336 @default.
• W2034273648 cites W1983831378 @default.
• W2034273648 cites W1985968438 @default.
• W2034273648 cites W1991484745 @default.
• W2034273648 cites W1991587314 @default.
• W2034273648 cites W1992069089 @default.
• W2034273648 cites W1995899156 @default.
• W2034273648 cites W1996189712 @default.
• W2034273648 cites W1997779165 @default.
• W2034273648 cites W1999454445 @default.
• W2034273648 cites W1999777474 @default.
• W2034273648 cites W2000252729 @default.
• W2034273648 cites W2000306425 @default.
• W2034273648 cites W2007233596 @default.
• W2034273648 cites W2015648089 @default.
• W2034273648 cites W2021200445 @default.
• W2034273648 cites W2022573440 @default.
• W2034273648 cites W2024689125 @default.
• W2034273648 cites W2025415352 @default.
• W2034273648 cites W2026187249 @default.
• W2034273648 cites W2030446660 @default.
• W2034273648 cites W2035885829 @default.
• W2034273648 cites W2039984019 @default.
• W2034273648 cites W2042497887 @default.
• W2034273648 cites W2046110288 @default.
• W2034273648 cites W2050357864 @default.
• W2034273648 cites W2057241678 @default.
• W2034273648 cites W2057307047 @default.
• W2034273648 cites W2057628120 @default.
• W2034273648 cites W2059857046 @default.
• W2034273648 cites W2062971078 @default.
• W2034273648 cites W2072842460 @default.
• W2034273648 cites W2077936658 @default.
• W2034273648 cites W2079353889 @default.
• W2034273648 cites W2087704727 @default.
• W2034273648 cites W2088749065 @default.
• W2034273648 cites W2095391491 @default.
• W2034273648 cites W2099241233 @default.
• W2034273648 cites W2101746871 @default.
• W2034273648 cites W2104119127 @default.
• W2034273648 cites W2108799394 @default.
• W2034273648 cites W2113759120 @default.
• W2034273648 cites W2118397392 @default.
• W2034273648 cites W2143965788 @default.
• W2034273648 cites W2147843482 @default.
• W2034273648 cites W2151984737 @default.
• W2034273648 cites W2157674842 @default.
• W2034273648 cites W2402785197 @default.
• W2034273648 cites W947993294 @default.
• W2034273648 doi "https://doi.org/10.1002/neu.480280302" @default.
• W2034273648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8568510" @default.
• W2034273648 hasPublicationYear "1995" @default.
• W2034273648 type Work @default.
• W2034273648 sameAs 2034273648 @default.
• W2034273648 citedByCount "74" @default.
• W2034273648 countsByYear W20342736482012 @default.
• W2034273648 countsByYear W20342736482013 @default.
• W2034273648 countsByYear W20342736482014 @default.
• W2034273648 countsByYear W20342736482015 @default.
• W2034273648 countsByYear W20342736482016 @default.
• W2034273648 countsByYear W20342736482017 @default.
• W2034273648 countsByYear W20342736482018 @default.
• W2034273648 countsByYear W20342736482019 @default.
• W2034273648 countsByYear W20342736482020 @default.
• W2034273648 countsByYear W20342736482021 @default.
• W2034273648 countsByYear W20342736482022 @default.
• W2034273648 countsByYear W20342736482023 @default.
• W2034273648 crossrefType "journal-article" @default.
• W2034273648 hasAuthorship W2034273648A5041890940 @default.
• W2034273648 hasAuthorship W2034273648A5086368037 @default.
• W2034273648 hasConcept C104317684 @default.
• W2034273648 hasConcept C126322002 @default.
• W2034273648 hasConcept C134018914 @default.
• W2034273648 hasConcept C13852961 @default.
• W2034273648 hasConcept C169760540 @default.
• W2034273648 hasConcept C170493617 @default.
• W2034273648 hasConcept C2777953023 @default.
• W2034273648 hasConcept C2779535977 @default.

• next