FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034274612> ?p ?o ?g. }

• W2034274612 endingPage "e88040" @default.
• W2034274612 startingPage "e88040" @default.
• W2034274612 abstract "Expression of matrix metalloproteinase-1 (MMP-1), an interstitial collagenase, plays a major role in cellular invasion during development of gastric cancer, a leading cause of death worldwide. A single-nucleotide polymorphism (SNP) −1607 1G/2G site of the MMP-1 gene promoter has been reported to alter transcription level. While the importance’s of other SNPs in the MMP-1 promoter have not yet been studied in gastric cancer, our aim was to investigate MMP-1 gene promoter polymorphisms and gastric cancer susceptibility in eastern Indian population. A total of 145 gastric cancer patients and 145 healthy controls were genotyped for MMP-1 −1607 1G/2G (rs1799750) by PCR-restriction fragment length polymorphism (RFLP), while MMP-1 −519 A/G (rs1144393), MMP-1 −422 T/A (rs475007), MMP-1 −340 T/C (rs514921) and MMP-1 −320 T/C (rs494379) were genotyped by DNA sequencing. A positive association was found with MMP-1 −422 T/A SNP that showed significant risk for regional lymph node metastasis (P = 0.021, Odd’s ratio (OR) = 3.044, Confidence intervals (CI) = 1.187–7.807). In addition, we found a significant association with lower stomach tumor formation among gastric cancer patients for three adjacent polymorphisms near the transcriptional start sites of [MMP-1 −422 T/A (P = 0.043, OR = 2.182, CI = 1.03–4.643), MMP-1 −340 T/C (P = 0.075, OR = 1.97, CI = 0.94–4.158) and MMP-1 −320 T/C (P = 0.034, OR = 2.224, CI = 1.064–40731)]. MMP-1 level in patients’ serum was correlated with MMP-1 promoter haplotypes conferring these three SNPs to evaluate the functional importance of these polymorphisms in lower stomach tumor formation and significant correlation was observed. Furthermore, MMP-1 −519 A/G polymorphism displayed poor cellular differentiation (P = 0.024, OR = 3.8, CI = 1.69–8.56) attributing a higher risk of cancer progression. In conclusion, MMP-1 proximal promoter SNPs are associated with the risk of lower stomach tumor formation and node metastasis in eastern Indian population." @default.
• W2034274612 created "2016-06-24" @default.
• W2034274612 creator A5009648827 @default.
• W2034274612 creator A5021587670 @default.
• W2034274612 creator A5034645382 @default.
• W2034274612 creator A5056350390 @default.
• W2034274612 creator A5062747949 @default.
• W2034274612 creator A5047550567 @default.
• W2034274612 date "2014-02-05" @default.
• W2034274612 modified "2023-09-23" @default.
• W2034274612 title "Matrix Metalloproteinase-1 (MMP-1) Promoter Polymorphisms are Well Linked with Lower Stomach Tumor Formation in Eastern Indian Population" @default.
• W2034274612 cites W170289634 @default.
• W2034274612 cites W1973789978 @default.
• W2034274612 cites W1979286057 @default.
• W2034274612 cites W1980343471 @default.
• W2034274612 cites W1981989535 @default.
• W2034274612 cites W1983729225 @default.
• W2034274612 cites W1986612792 @default.
• W2034274612 cites W1998342236 @default.
• W2034274612 cites W2003165120 @default.
• W2034274612 cites W2005521257 @default.
• W2034274612 cites W2015444330 @default.
• W2034274612 cites W2044828823 @default.
• W2034274612 cites W2056881651 @default.
• W2034274612 cites W2062100234 @default.
• W2034274612 cites W2065493263 @default.
• W2034274612 cites W2069300982 @default.
• W2034274612 cites W2070960014 @default.
• W2034274612 cites W2081172418 @default.
• W2034274612 cites W2090197643 @default.
• W2034274612 cites W2101364916 @default.
• W2034274612 cites W2102058612 @default.
• W2034274612 cites W2104692426 @default.
• W2034274612 cites W2117262139 @default.
• W2034274612 cites W2117879926 @default.
• W2034274612 cites W2118608802 @default.
• W2034274612 cites W2123663350 @default.
• W2034274612 cites W2133794263 @default.
• W2034274612 cites W2136007508 @default.
• W2034274612 cites W2152664025 @default.
• W2034274612 cites W2155873728 @default.
• W2034274612 cites W2161633633 @default.
• W2034274612 cites W2162530578 @default.
• W2034274612 cites W2169593908 @default.
• W2034274612 cites W2418176446 @default.
• W2034274612 doi "https://doi.org/10.1371/journal.pone.0088040" @default.
• W2034274612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3914871" @default.
• W2034274612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24505369" @default.
• W2034274612 hasPublicationYear "2014" @default.
• W2034274612 type Work @default.
• W2034274612 sameAs 2034274612 @default.
• W2034274612 citedByCount "24" @default.
• W2034274612 countsByYear W20342746122014 @default.
• W2034274612 countsByYear W20342746122015 @default.
• W2034274612 countsByYear W20342746122016 @default.
• W2034274612 countsByYear W20342746122017 @default.
• W2034274612 countsByYear W20342746122018 @default.
• W2034274612 countsByYear W20342746122019 @default.
• W2034274612 countsByYear W20342746122020 @default.
• W2034274612 countsByYear W20342746122021 @default.
• W2034274612 countsByYear W20342746122022 @default.
• W2034274612 crossrefType "journal-article" @default.
• W2034274612 hasAuthorship W2034274612A5009648827 @default.
• W2034274612 hasAuthorship W2034274612A5021587670 @default.
• W2034274612 hasAuthorship W2034274612A5034645382 @default.
• W2034274612 hasAuthorship W2034274612A5047550567 @default.
• W2034274612 hasAuthorship W2034274612A5056350390 @default.
• W2034274612 hasAuthorship W2034274612A5062747949 @default.
• W2034274612 hasBestOaLocation W20342746121 @default.
• W2034274612 hasConcept C101762097 @default.
• W2034274612 hasConcept C104317684 @default.
• W2034274612 hasConcept C109523444 @default.
• W2034274612 hasConcept C121608353 @default.
• W2034274612 hasConcept C126322002 @default.
• W2034274612 hasConcept C135763542 @default.
• W2034274612 hasConcept C139275648 @default.
• W2034274612 hasConcept C150194340 @default.
• W2034274612 hasConcept C153209595 @default.
• W2034274612 hasConcept C153911025 @default.
• W2034274612 hasConcept C156957248 @default.
• W2034274612 hasConcept C2779013556 @default.
• W2034274612 hasConcept C2779422922 @default.
• W2034274612 hasConcept C2779454504 @default.
• W2034274612 hasConcept C2908647359 @default.
• W2034274612 hasConcept C54355233 @default.
• W2034274612 hasConcept C71924100 @default.
• W2034274612 hasConcept C86803240 @default.
• W2034274612 hasConcept C90924648 @default.
• W2034274612 hasConcept C99454951 @default.
• W2034274612 hasConceptScore W2034274612C101762097 @default.
• W2034274612 hasConceptScore W2034274612C104317684 @default.
• W2034274612 hasConceptScore W2034274612C109523444 @default.
• W2034274612 hasConceptScore W2034274612C121608353 @default.
• W2034274612 hasConceptScore W2034274612C126322002 @default.
• W2034274612 hasConceptScore W2034274612C135763542 @default.
• W2034274612 hasConceptScore W2034274612C139275648 @default.
• W2034274612 hasConceptScore W2034274612C150194340 @default.
• W2034274612 hasConceptScore W2034274612C153209595 @default.

• next