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- W2034276013 abstract "To evaluate the rates of the CYP1A1 Ile/Val polymorphism in Turkish adolescent females.The CYP1A1 Ile/Val polymorphism was analyzed by collecting DNA samples from 44 adolescents with polycystic ovary syndrome (PCOS)--according to the Rotterdam criteria--and 120 healthy female controls aged 13-18 years in Ankara, Turkey.There was a 2.5-fold increase in the frequency of the CYP1A1 Ile/Val genotype in adolescents with PCOS compared with the control group (odds ratio [OR] 2.54; 95% confidence interval [CI], 1.143-5.637; P<0.001), in addition to a 2.4-fold increase in the frequency of the Val allele (OR 2.43; 95% CI, 1.099-5.397; P<0.001).The data show an association between CYP1A1 and PCOS, indicating that variant alleles of the gene may affect the metabolic and transport pathway of estrogens, thus causing PCOS." @default.
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- W2034276013 date "2010-10-20" @default.
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- W2034276013 title "<i>CYP1A1</i>polymorphism in adolescents with polycystic ovary syndrome" @default.
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- W2034276013 doi "https://doi.org/10.1016/j.ijgo.2010.07.032" @default.
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