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• W2034277681 endingPage "1055" @default.
• W2034277681 startingPage "1051" @default.
• W2034277681 abstract "The present study examines the effect of chronic treatment of glucocorticoids on ACTHi.24-or forskolin-induced cAMP output of cultured sheep adrenocortical cells. Cells cultured for 2 days in the presence of 1 μM dexamethasone released more cAMP in response to ACTH1.24 than did untreated cells, both in the absence and presence of 0.5 mM l-methyl-3-isobutylxanthine. Such an enhancing effect required greater than or equal to 21 h of treatment and was both concentration-dependent and steroid specific. The ED50 of dexamethasone was about 10 nM, while that of cortisol and corticosterone was about 1 μM; testosterone at concentrations less than or equal to 10-5 M had no enhancing effect. Glucocorticoids enhanced the cAMP response to ACTH1.24 without altering its ED50. Treatment of cultures with aminoglutethimide or the antiglucocorticoid RU 38486 for 48 h resulted in a dose-dependent decrease in ACTH1.24-induced cAMP output. Moreover, RU 38486 antagonized the enhancing effect of dexamethasone. Glucocorticoids did not increase the cAMP response to forskolin. These results suggest that chronic exposure to glucocorticoids is necessary for the full expression of the cAMP response to ACTH1.24 of adrenocortical cells from adult sheep. (Endocrinology121: 1051–1055,1987)" @default.
• W2034277681 created "2016-06-24" @default.
• W2034277681 creator A5024565466 @default.
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• W2034277681 date "1987-09-01" @default.
• W2034277681 modified "2023-10-02" @default.
• W2034277681 title "Glucocorticoid Enhancement of Adrenocorticotropin Induced 3′,5′-Cyclic Adenosine Monophosphate Production by Cultured Ovine Adrenocortical Cells*" @default.
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• W2034277681 doi "https://doi.org/10.1210/endo-121-3-1051" @default.
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