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• W2034277769 startingPage "60" @default.
• W2034277769 abstract "The morphology of the astrocyte was studied with the electron microscope in the posterior gray and at the edge of the spinal cord, in both normal adult rats and after crush lesion of dorsal roots in adult rats. In general, the astrocyte was characterized by a pale, round nucleus surrounded by a cytoplasm containing small bundles of filaments and few organelles. However, the subpial astrocyte appeared to possess a larger amount of filaments. Within 4 days after injury, the astrocytes responded by accumulating glycogen particles within their cytoplasm even in the absence of morphological evidence of damage to nerve fibers. In addition, the astrocytic nucleus appeared reactive as evidenced by a tendency to increased nuclear irregularity, nuclear pores, and prominent nucleoli. The cytoplasm of several astrocytes also displayed hypertrophy resulting in accumulation of microfilaments, mitochondria, multiple Golgi complexes, and several electron-dense bodies. In animals killed 4 weeks after lesion, clear evidence of astrocytes functioning as macrophages in the removal of degenerating myelin was observed. These reactive astrocytes exhibited multiple Golgi complexes, large amounts of microfilaments, and numerous mitochondria. The subpial astrocytes especially possessed an abundance of microfilaments." @default.
• W2034277769 created "2016-06-24" @default.
• W2034277769 creator A5029614462 @default.
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• W2034277769 date "1977-01-01" @default.
• W2034277769 modified "2023-10-15" @default.
• W2034277769 title "Astroglial response to degeneration of dorsal root fibers in adult rat spinal cord" @default.
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• W2034277769 doi "https://doi.org/10.1016/0014-4886(77)90235-7" @default.
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