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• W2034277897 abstract "The rat pituitary cell line, MtT/SM, has the characteristics of somatomammotrophs. The cells secrete both prolactin (PRL) and growth hormone (GH). We examined the effects of cytokines such as leukaemia inhibitory factor (LIF), interleukin 6 (IL-6), oncostatin M and interleukin 11 on the secretion of these hormones by the cells. These cytokines stimulate proliferation of the cells and inhibit the secretion of PRL by 70–80% and that of GH by 50%. They induce tyrosine phosphorylation of STAT3 in the cells. The cells containing PRL or GH decreased at 48 h after treatment of the cells with LIF or IL-6. These results suggest that the LIF/IL-6 family of cytokines inhibits the functions of mammotrophs and somatotrophs in the pituitary gland." @default.
• W2034277897 created "2016-06-24" @default.
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• W2034277897 date "2001-05-01" @default.
• W2034277897 modified "2023-09-25" @default.
• W2034277897 title "LEUKAEMIA INHIBITORY FACTOR AND INTERLEUKIN 6 INHIBIT SECRETION OF PROLACTIN AND GROWTH HORMONE BY RAT PITUITARY MtT/SM CELLS" @default.
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• W2034277897 doi "https://doi.org/10.1006/cyto.2001.0874" @default.
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