Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034278019> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2034278019 abstract "To evaluate the drug constitution of dantrolene by comparing reconstitution with diluent at ambient and warmed temperatures, so as to determine whether differences in reconstitution time might provide clinical or therapeutic advantages.Randomized study.University-affiliated medical center.We reconstituted 10 vials of dantrolene, 5 with room-temperature diluent (sterile water) and 5 with diluent warmed to approximately 41 degrees C. Injection of diluent (10 seconds) was followed by 5 seconds of observation and recurring 15-second cycles (10 seconds of moderate manual agitation followed by 5 seconds of observation) until full reconstitution. In a second series of reconstitutions, warmed diluent injection was immediately followed by predetermined lengths of moderate manual agitation, and reconstitution status was noted at the end of each trial. Time to full reconstitution was based on a series of predetermined objective criteria. In experiment 1, with ambient-temperature diluent (22.0 degrees C -23.1 degrees C), reconstitution occurred in 90 to 130 seconds; whereas warmed diluent (40.7 degrees C-41.3 degrees C) reconstitution occurred in less than 30 seconds (P<0.004). In experiment 2, with warmed diluent (40.9 degrees C), full reconstitution occurred after 10 seconds of injection and 18 seconds of moderate manual agitation.The use of prewarmed diluent to 41 degrees C significantly reduces dantrolene reconstitution time. Further studies should evaluate the efficacy of dantrolene reconstituted with warmed diluent." @default.
- W2034278019 created "2016-06-24" @default.
- W2034278019 creator A5026462426 @default.
- W2034278019 creator A5045441625 @default.
- W2034278019 creator A5071048004 @default.
- W2034278019 date "2006-08-01" @default.
- W2034278019 modified "2023-09-25" @default.
- W2034278019 title "Dantrolene reconstitution: can warmed diluent make a difference?" @default.
- W2034278019 cites W1552317094 @default.
- W2034278019 cites W2077256882 @default.
- W2034278019 cites W2148269081 @default.
- W2034278019 cites W2278515430 @default.
- W2034278019 cites W2315710586 @default.
- W2034278019 cites W2581046737 @default.
- W2034278019 doi "https://doi.org/10.1016/j.jclinane.2006.04.001" @default.
- W2034278019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16905078" @default.
- W2034278019 hasPublicationYear "2006" @default.
- W2034278019 type Work @default.
- W2034278019 sameAs 2034278019 @default.
- W2034278019 citedByCount "7" @default.
- W2034278019 countsByYear W20342780192015 @default.
- W2034278019 countsByYear W20342780192016 @default.
- W2034278019 crossrefType "journal-article" @default.
- W2034278019 hasAuthorship W2034278019A5026462426 @default.
- W2034278019 hasAuthorship W2034278019A5045441625 @default.
- W2034278019 hasAuthorship W2034278019A5071048004 @default.
- W2034278019 hasConcept C126322002 @default.
- W2034278019 hasConcept C13965031 @default.
- W2034278019 hasConcept C175804951 @default.
- W2034278019 hasConcept C185592680 @default.
- W2034278019 hasConcept C2781460320 @default.
- W2034278019 hasConcept C42219234 @default.
- W2034278019 hasConcept C43617362 @default.
- W2034278019 hasConcept C519063684 @default.
- W2034278019 hasConcept C71924100 @default.
- W2034278019 hasConcept C72092618 @default.
- W2034278019 hasConceptScore W2034278019C126322002 @default.
- W2034278019 hasConceptScore W2034278019C13965031 @default.
- W2034278019 hasConceptScore W2034278019C175804951 @default.
- W2034278019 hasConceptScore W2034278019C185592680 @default.
- W2034278019 hasConceptScore W2034278019C2781460320 @default.
- W2034278019 hasConceptScore W2034278019C42219234 @default.
- W2034278019 hasConceptScore W2034278019C43617362 @default.
- W2034278019 hasConceptScore W2034278019C519063684 @default.
- W2034278019 hasConceptScore W2034278019C71924100 @default.
- W2034278019 hasConceptScore W2034278019C72092618 @default.
- W2034278019 hasLocation W20342780191 @default.
- W2034278019 hasLocation W20342780192 @default.
- W2034278019 hasOpenAccess W2034278019 @default.
- W2034278019 hasPrimaryLocation W20342780191 @default.
- W2034278019 hasRelatedWork W1967219443 @default.
- W2034278019 hasRelatedWork W2019086812 @default.
- W2034278019 hasRelatedWork W2034278019 @default.
- W2034278019 hasRelatedWork W2111028676 @default.
- W2034278019 hasRelatedWork W2406077752 @default.
- W2034278019 hasRelatedWork W2414200593 @default.
- W2034278019 hasRelatedWork W2416896280 @default.
- W2034278019 hasRelatedWork W2417587287 @default.
- W2034278019 hasRelatedWork W2912556826 @default.
- W2034278019 hasRelatedWork W2917524362 @default.
- W2034278019 isParatext "false" @default.
- W2034278019 isRetracted "false" @default.
- W2034278019 magId "2034278019" @default.
- W2034278019 workType "article" @default.