Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034278640> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2034278640 endingPage "37" @default.
- W2034278640 startingPage "31" @default.
- W2034278640 abstract "Melanin-concentrating hormone (MCH) is a peptide that has been isolated from salmon pituitary and rat hypothalamus. In mammals, pro-MCH (PMCH) encodes two putative peptides, named NEI and NGE, in addition to MCH. Those peptides are expressed predominantly in hypothalamus and display a broad array of functions in rat brain. We have previously mapped the PMCH locus on human chromosome 12q and rat chromosome 7. Genomic cloning has revealed the existence of two distinct MCH genes in human: one authentic and one variant. In this report, we describe Southern blotting analysis with DNA from a panel of somatic cell hybrids and demonstrate that the authentic human MCH (hMCH) gene is located as expected on chromosome 12, while the variant form of hMCH gene is located on chromosome 5. Direct chromosomal assignment of the authentic and variant hMCH genes was obtained by using fluorescence in situ hybridization on metaphase chromosomes. A strong signal was observed in 12q23-q24 with the authentic hMCH genomic DNA probe. Surprisingly, two signals were conspicuously found in 5p14 and 5q12-q13 with different variant hMCH genomic DNA probes. These loci were designated PMCHL1 and PMCHL2. Evidence of physiological and pathological data in rodents together with locus linkage analyses in human suggests that hMCH authentic and variant genes may be involved in human brain disorders." @default.
- W2034278640 created "2016-06-24" @default.
- W2034278640 creator A5067204984 @default.
- W2034278640 creator A5078180070 @default.
- W2034278640 creator A5087907084 @default.
- W2034278640 date "1994-01-01" @default.
- W2034278640 modified "2023-10-17" @default.
- W2034278640 title "Assignment of the Human Pro-Melanin-Concentrating Hormone Gene (PMCH) to Chromosome 12q23-q24 and Two Variant Genes (PMCHL1 and PMCHL2) to Chromosome 5p14 and 5q12-q13" @default.
- W2034278640 doi "https://doi.org/10.1006/geno.1994.1008" @default.
- W2034278640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8188237" @default.
- W2034278640 hasPublicationYear "1994" @default.
- W2034278640 type Work @default.
- W2034278640 sameAs 2034278640 @default.
- W2034278640 citedByCount "33" @default.
- W2034278640 countsByYear W20342786402014 @default.
- W2034278640 countsByYear W20342786402016 @default.
- W2034278640 countsByYear W20342786402018 @default.
- W2034278640 countsByYear W20342786402021 @default.
- W2034278640 crossrefType "journal-article" @default.
- W2034278640 hasAuthorship W2034278640A5067204984 @default.
- W2034278640 hasAuthorship W2034278640A5078180070 @default.
- W2034278640 hasAuthorship W2034278640A5087907084 @default.
- W2034278640 hasConcept C104317684 @default.
- W2034278640 hasConcept C109748351 @default.
- W2034278640 hasConcept C122735190 @default.
- W2034278640 hasConcept C141231307 @default.
- W2034278640 hasConcept C167752854 @default.
- W2034278640 hasConcept C17757408 @default.
- W2034278640 hasConcept C197077220 @default.
- W2034278640 hasConcept C2777542201 @default.
- W2034278640 hasConcept C30481170 @default.
- W2034278640 hasConcept C54355233 @default.
- W2034278640 hasConcept C84597430 @default.
- W2034278640 hasConcept C86803240 @default.
- W2034278640 hasConceptScore W2034278640C104317684 @default.
- W2034278640 hasConceptScore W2034278640C109748351 @default.
- W2034278640 hasConceptScore W2034278640C122735190 @default.
- W2034278640 hasConceptScore W2034278640C141231307 @default.
- W2034278640 hasConceptScore W2034278640C167752854 @default.
- W2034278640 hasConceptScore W2034278640C17757408 @default.
- W2034278640 hasConceptScore W2034278640C197077220 @default.
- W2034278640 hasConceptScore W2034278640C2777542201 @default.
- W2034278640 hasConceptScore W2034278640C30481170 @default.
- W2034278640 hasConceptScore W2034278640C54355233 @default.
- W2034278640 hasConceptScore W2034278640C84597430 @default.
- W2034278640 hasConceptScore W2034278640C86803240 @default.
- W2034278640 hasIssue "1" @default.
- W2034278640 hasLocation W20342786401 @default.
- W2034278640 hasLocation W20342786402 @default.
- W2034278640 hasOpenAccess W2034278640 @default.
- W2034278640 hasPrimaryLocation W20342786401 @default.
- W2034278640 hasRelatedWork W1866648957 @default.
- W2034278640 hasRelatedWork W1967255255 @default.
- W2034278640 hasRelatedWork W2006421495 @default.
- W2034278640 hasRelatedWork W2019692718 @default.
- W2034278640 hasRelatedWork W2033968870 @default.
- W2034278640 hasRelatedWork W2051023487 @default.
- W2034278640 hasRelatedWork W2096453794 @default.
- W2034278640 hasRelatedWork W2117337209 @default.
- W2034278640 hasRelatedWork W2155060720 @default.
- W2034278640 hasRelatedWork W4206511740 @default.
- W2034278640 hasVolume "19" @default.
- W2034278640 isParatext "false" @default.
- W2034278640 isRetracted "false" @default.
- W2034278640 magId "2034278640" @default.
- W2034278640 workType "article" @default.