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• W2034278983 abstract "Calorie restriction (CR) slows aging in numerous species. In the yeast Saccharomyces cerevisiae, this effect requires Sir2, a conserved NAD+-dependent deacetylase. We report that CR reduces nuclear NAD+ levels in vivo. Moreover, the activity of Sir2 and its human homologue SIRT1 are not affected by physiological alterations in the NAD+:NADH ratio. These data implicate alternate mechanisms of Sir2 regulation by CR." @default.
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• W2034278983 date "2003-12-19" @default.
• W2034278983 modified "2023-10-16" @default.
• W2034278983 title "Yeast Life-Span Extension by Calorie Restriction Is Independent of NAD Fluctuation" @default.
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• W2034278983 doi "https://doi.org/10.1126/science.1088697" @default.
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