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• W2034279059 abstract "Sex differences have been observed in antinociception following central administration of morphine into either the lateral ventricles or rostral ventromedial medulla (RVM) such that male rats exhibit significantly greater antinociception than female rats. The present study examined whether sex and adult gonadectomy differences were observed in morphine-induced (1-10 micrograms) antinociception elicited from the ventrolateral periaqueductal gray (vlPAG) on two nociceptive measures. Both sham-operated (ED50=1.20-1.60 microgram) and castrated (ED50=1.08-1.09 micrograms) male rats displayed significantly greater magnitudes and potencies of morphine-induced antinociception on both tests than female rats. Sham-operated female rats tested during the estrous phase (ED50=>50 micrograms) were significantly less sensitive to morphine than ovariectomized female rats (ED50=1.98-2. 51 micrograms). Thus, the vlPAG, a site sensitive to interactions between estradiol-containing hypothalamic loci and opioid peptides, elicits morphine-induced antinociception which is sensitive to sex differences and adult gonadectomy." @default.
• W2034279059 created "2016-06-24" @default.
• W2034279059 creator A5080196369 @default.
• W2034279059 creator A5090495819 @default.
• W2034279059 date "1999-03-01" @default.
• W2034279059 modified "2023-10-14" @default.
• W2034279059 title "Morphine antinociception elicited from the ventrolateral periaqueductal gray is sensitive to sex and gonadectomy differences in rats" @default.
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• W2034279059 doi "https://doi.org/10.1016/s0006-8993(98)01364-x" @default.
• W2034279059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10064807" @default.
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