Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034280427> ?p ?o ?g. }
- W2034280427 endingPage "501" @default.
- W2034280427 startingPage "493" @default.
- W2034280427 abstract "A series of new steroidal 4H-pyrans (4-6) have been synthesized from steroidal α, β-unsaturated ketones (1-3). The products (4-6) were characterized by IR, (1)H NMR, (13)C NMR, MS and analytical data. The interaction studies of compounds (4-6) with DNA were carried out by employing gel electrophoresis, UV-vis and fluorescence spectroscopy. The gel electrophoresis pattern revealed that compounds (4-6) bind to DNA and also demonstrated that the compound 6 alone or in presence of Cu (II) causes the nicking of supercoiled pBR322. The compounds 4 and 5 bind to DNA preferentially through electrostatic and hydrophobic interactions with Kb values found to be 5.3×10(3) and 3.7×10(3) M(-1), respectively, indicating the higher binding affinity of compound 4 towards DNA. The docking study suggested the intercalation of compounds in between the nucleotide base pairs. The cytotoxicity and genotoxicity of the newly synthesized compounds were checked by MTT and comet assay, respectively during which compound 6 showed potential behaviour." @default.
- W2034280427 created "2016-06-24" @default.
- W2034280427 creator A5003246382 @default.
- W2034280427 creator A5005252545 @default.
- W2034280427 creator A5029078041 @default.
- W2034280427 creator A5043231856 @default.
- W2034280427 creator A5056289112 @default.
- W2034280427 creator A5064885586 @default.
- W2034280427 date "2014-01-01" @default.
- W2034280427 modified "2023-10-16" @default.
- W2034280427 title "Synthesis, molecular docking and biological evaluation of new steroidal 4H-pyrans" @default.
- W2034280427 cites W1970604424 @default.
- W2034280427 cites W1973930277 @default.
- W2034280427 cites W1977642913 @default.
- W2034280427 cites W1978245859 @default.
- W2034280427 cites W1983649348 @default.
- W2034280427 cites W1993582814 @default.
- W2034280427 cites W1998659512 @default.
- W2034280427 cites W1998751682 @default.
- W2034280427 cites W2004090019 @default.
- W2034280427 cites W2004775205 @default.
- W2034280427 cites W2005445364 @default.
- W2034280427 cites W2008215248 @default.
- W2034280427 cites W2009696322 @default.
- W2034280427 cites W2014804954 @default.
- W2034280427 cites W2020931127 @default.
- W2034280427 cites W2024931990 @default.
- W2034280427 cites W2029622237 @default.
- W2034280427 cites W2030133358 @default.
- W2034280427 cites W2034530507 @default.
- W2034280427 cites W2042303045 @default.
- W2034280427 cites W2044834744 @default.
- W2034280427 cites W2046421277 @default.
- W2034280427 cites W2047136594 @default.
- W2034280427 cites W2050942083 @default.
- W2034280427 cites W2053330758 @default.
- W2034280427 cites W2060697882 @default.
- W2034280427 cites W2062542146 @default.
- W2034280427 cites W2063604710 @default.
- W2034280427 cites W2065071409 @default.
- W2034280427 cites W2069801614 @default.
- W2034280427 cites W2085913223 @default.
- W2034280427 cites W2087281285 @default.
- W2034280427 cites W2087752336 @default.
- W2034280427 cites W2089476471 @default.
- W2034280427 cites W2090919729 @default.
- W2034280427 cites W2092605043 @default.
- W2034280427 cites W2095010690 @default.
- W2034280427 cites W2114918609 @default.
- W2034280427 cites W2122961785 @default.
- W2034280427 cites W2146080367 @default.
- W2034280427 cites W2149710856 @default.
- W2034280427 cites W2157567077 @default.
- W2034280427 cites W2157805786 @default.
- W2034280427 cites W4254437031 @default.
- W2034280427 cites W77781818 @default.
- W2034280427 doi "https://doi.org/10.1016/j.saa.2013.08.019" @default.
- W2034280427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24021949" @default.
- W2034280427 hasPublicationYear "2014" @default.
- W2034280427 type Work @default.
- W2034280427 sameAs 2034280427 @default.
- W2034280427 citedByCount "4" @default.
- W2034280427 countsByYear W20342804272017 @default.
- W2034280427 countsByYear W20342804272018 @default.
- W2034280427 countsByYear W20342804272020 @default.
- W2034280427 countsByYear W20342804272023 @default.
- W2034280427 crossrefType "journal-article" @default.
- W2034280427 hasAuthorship W2034280427A5003246382 @default.
- W2034280427 hasAuthorship W2034280427A5005252545 @default.
- W2034280427 hasAuthorship W2034280427A5029078041 @default.
- W2034280427 hasAuthorship W2034280427A5043231856 @default.
- W2034280427 hasAuthorship W2034280427A5056289112 @default.
- W2034280427 hasAuthorship W2034280427A5064885586 @default.
- W2034280427 hasConcept C103319777 @default.
- W2034280427 hasConcept C109316439 @default.
- W2034280427 hasConcept C116084860 @default.
- W2034280427 hasConcept C137824038 @default.
- W2034280427 hasConcept C143425029 @default.
- W2034280427 hasConcept C159110408 @default.
- W2034280427 hasConcept C178790620 @default.
- W2034280427 hasConcept C185592680 @default.
- W2034280427 hasConcept C202751555 @default.
- W2034280427 hasConcept C2778959862 @default.
- W2034280427 hasConcept C2780358455 @default.
- W2034280427 hasConcept C2780783641 @default.
- W2034280427 hasConcept C29730261 @default.
- W2034280427 hasConcept C41685203 @default.
- W2034280427 hasConcept C552990157 @default.
- W2034280427 hasConcept C55493867 @default.
- W2034280427 hasConcept C71240020 @default.
- W2034280427 hasConcept C71924100 @default.
- W2034280427 hasConceptScore W2034280427C103319777 @default.
- W2034280427 hasConceptScore W2034280427C109316439 @default.
- W2034280427 hasConceptScore W2034280427C116084860 @default.
- W2034280427 hasConceptScore W2034280427C137824038 @default.
- W2034280427 hasConceptScore W2034280427C143425029 @default.
- W2034280427 hasConceptScore W2034280427C159110408 @default.
- W2034280427 hasConceptScore W2034280427C178790620 @default.