Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034280502> ?p ?o ?g. }
- W2034280502 endingPage "12966" @default.
- W2034280502 startingPage "12956" @default.
- W2034280502 abstract "The initial formation and growth of dendrites is a critical step leading to the integration of newly generated neurons into postnatal functional networks. However, the cellular mechanisms and extracellular signals regulating this process remain mostly unknown. By directly observing newborn neurons derived from the subventricular zone in culture as well as in olfactory bulb slices, we show that ambient GABA acting through GABA(A) receptors is essential for the temporal stability of lamellipodial protrusions in dendritic growth cones but did not interfere with filopodia dynamics. Furthermore, we provide direct evidence that ambient GABA is required for the proper initiation and elongation of dendrites by promoting the rapid stabilization of new dendritic segments after their extension. The effects of GABA on the initial formation of dendrites depend on depolarization and Ca2+ influx and are associated with a higher stability of microtubules. Together, our results indicate that ambient GABA is a key regulator of dendritic initiation in postnatally generated olfactory interneurons and offer a mechanism by which this neurotransmitter drives early dendritic growth." @default.
- W2034280502 created "2016-06-24" @default.
- W2034280502 creator A5005773106 @default.
- W2034280502 creator A5011425786 @default.
- W2034280502 creator A5013597897 @default.
- W2034280502 creator A5038583304 @default.
- W2034280502 creator A5049765660 @default.
- W2034280502 creator A5063888708 @default.
- W2034280502 creator A5065355943 @default.
- W2034280502 creator A5075365580 @default.
- W2034280502 creator A5079561004 @default.
- W2034280502 creator A5080520407 @default.
- W2034280502 date "2006-12-13" @default.
- W2034280502 modified "2023-09-27" @default.
- W2034280502 title "GABA Regulates Dendritic Growth by Stabilizing Lamellipodia in Newly Generated Interneurons of the Olfactory Bulb" @default.
- W2034280502 cites W1487852103 @default.
- W2034280502 cites W1588629441 @default.
- W2034280502 cites W1892249233 @default.
- W2034280502 cites W1893566722 @default.
- W2034280502 cites W1968871740 @default.
- W2034280502 cites W1973523055 @default.
- W2034280502 cites W1976054166 @default.
- W2034280502 cites W1983672552 @default.
- W2034280502 cites W1988352722 @default.
- W2034280502 cites W1988866946 @default.
- W2034280502 cites W1996353639 @default.
- W2034280502 cites W2004528035 @default.
- W2034280502 cites W2007130804 @default.
- W2034280502 cites W2008224735 @default.
- W2034280502 cites W2028756363 @default.
- W2034280502 cites W2031863862 @default.
- W2034280502 cites W2033712349 @default.
- W2034280502 cites W2045103889 @default.
- W2034280502 cites W2048231004 @default.
- W2034280502 cites W2048525391 @default.
- W2034280502 cites W2052974794 @default.
- W2034280502 cites W2059787565 @default.
- W2034280502 cites W2060161122 @default.
- W2034280502 cites W2064363302 @default.
- W2034280502 cites W2064367025 @default.
- W2034280502 cites W2072962057 @default.
- W2034280502 cites W2077439063 @default.
- W2034280502 cites W2078981560 @default.
- W2034280502 cites W2080347303 @default.
- W2034280502 cites W2089710389 @default.
- W2034280502 cites W2095360553 @default.
- W2034280502 cites W2118447727 @default.
- W2034280502 cites W2121009504 @default.
- W2034280502 cites W2122787130 @default.
- W2034280502 cites W2125118099 @default.
- W2034280502 cites W2127812190 @default.
- W2034280502 cites W2134031827 @default.
- W2034280502 cites W2141471265 @default.
- W2034280502 cites W2147175479 @default.
- W2034280502 cites W2168300217 @default.
- W2034280502 cites W2320983896 @default.
- W2034280502 doi "https://doi.org/10.1523/jneurosci.4508-06.2006" @default.
- W2034280502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6674946" @default.
- W2034280502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17167085" @default.
- W2034280502 hasPublicationYear "2006" @default.
- W2034280502 type Work @default.
- W2034280502 sameAs 2034280502 @default.
- W2034280502 citedByCount "78" @default.
- W2034280502 countsByYear W20342805022012 @default.
- W2034280502 countsByYear W20342805022013 @default.
- W2034280502 countsByYear W20342805022014 @default.
- W2034280502 countsByYear W20342805022015 @default.
- W2034280502 countsByYear W20342805022016 @default.
- W2034280502 countsByYear W20342805022017 @default.
- W2034280502 countsByYear W20342805022018 @default.
- W2034280502 countsByYear W20342805022019 @default.
- W2034280502 countsByYear W20342805022020 @default.
- W2034280502 countsByYear W20342805022021 @default.
- W2034280502 countsByYear W20342805022022 @default.
- W2034280502 crossrefType "journal-article" @default.
- W2034280502 hasAuthorship W2034280502A5005773106 @default.
- W2034280502 hasAuthorship W2034280502A5011425786 @default.
- W2034280502 hasAuthorship W2034280502A5013597897 @default.
- W2034280502 hasAuthorship W2034280502A5038583304 @default.
- W2034280502 hasAuthorship W2034280502A5049765660 @default.
- W2034280502 hasAuthorship W2034280502A5063888708 @default.
- W2034280502 hasAuthorship W2034280502A5065355943 @default.
- W2034280502 hasAuthorship W2034280502A5075365580 @default.
- W2034280502 hasAuthorship W2034280502A5079561004 @default.
- W2034280502 hasAuthorship W2034280502A5080520407 @default.
- W2034280502 hasBestOaLocation W20342805021 @default.
- W2034280502 hasConcept C125705527 @default.
- W2034280502 hasConcept C169760540 @default.
- W2034280502 hasConcept C2524010 @default.
- W2034280502 hasConcept C2777222312 @default.
- W2034280502 hasConcept C2780496858 @default.
- W2034280502 hasConcept C33923547 @default.
- W2034280502 hasConcept C529278444 @default.
- W2034280502 hasConcept C84248122 @default.
- W2034280502 hasConcept C86803240 @default.
- W2034280502 hasConcept C90301020 @default.
- W2034280502 hasConcept C95444343 @default.
- W2034280502 hasConceptScore W2034280502C125705527 @default.