FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034280908> ?p ?o ?g. }

• W2034280908 endingPage "233" @default.
• W2034280908 startingPage "228" @default.
• W2034280908 abstract "The root of Polygonatum odoratum (YuZhu), also a medicinal food has long been used for the treatment of diabetes. The objective of the study was to characterize the anti-diabetic active fractions or compounds in this herb. Fractions with a different polarity were prepared by solvent extraction and macroporous absorptive resin (D101) column and their anti-diabetic potentials were evaluated by glucose uptake in HepG2 cells and STZ-induced diabetic rats. In addition, α-glycosidase inhibitory activities of active fractions were measured in vitro and chemical compositions including saponin, total flavonoids and total sugar in the fractions were determined. The n-buthanol fraction, a saponin-rich fraction obtained by partitioning the ethanol extract with n-buthanol after petroleum ether and acetic ether showed the highest anti-diabetic potential in glucose uptake in HepG2 cells followed by acetic ether fraction which was rich in flavonoids. Further fractionation the saponin-rich fraction using macroporous resin column (D101), polysaccharide, flavonoid and saponin rich fractions were obtained by elution with water, 40% and 60% ethanol, respectively and their anti-diabetic potentials proved by glucose uptake test in HepG2 cells and STZ-induced diabetic rats were in the order of saponin rich fraction > flavonoid rich fraction > polysaccharide rich fraction. Long-term therapy test (60 d) in severe diabetic rats indicated that saponin-rich fraction significantly ameliorated clinical symptoms of diabetes including the elevated blood glucose, body weight loss as well as the increased food and water intake while flavonoid-rich fraction was more potential than saponin-rich fraction to increase superoxide dismutase (SOD) activity and decrease malondialdehyde (MDA) level in rat plasma. Additionally, saponin-rich fraction and flavonoid-rich fraction showed α-glycosidase inhibitory activity with IC50 value of 2.05 ± 0.32 and 3.92 ± 0.65 mg/ml, respectively. The results suggested that saponin in this herb was more important than flavonoid in exhibiting anti-diabetic activity and flavonoid contributed more to anti-oxidant activity in vivo." @default.
• W2034280908 created "2016-06-24" @default.
• W2034280908 creator A5022332504 @default.
• W2034280908 creator A5026031019 @default.
• W2034280908 creator A5031224885 @default.
• W2034280908 creator A5042092772 @default.
• W2034280908 creator A5043213059 @default.
• W2034280908 creator A5058556732 @default.
• W2034280908 creator A5063240353 @default.
• W2034280908 creator A5069150872 @default.
• W2034280908 creator A5078863586 @default.
• W2034280908 creator A5083175225 @default.
• W2034280908 date "2012-05-01" @default.
• W2034280908 modified "2023-10-18" @default.
• W2034280908 title "Saponin rich fractions from Polygonatum odoratum (Mill.) Druce with more potential hypoglycemic effects" @default.
• W2034280908 cites W1723790989 @default.
• W2034280908 cites W1967487924 @default.
• W2034280908 cites W1974023205 @default.
• W2034280908 cites W1991189992 @default.
• W2034280908 cites W1995715507 @default.
• W2034280908 cites W1999302387 @default.
• W2034280908 cites W2009777379 @default.
• W2034280908 cites W2011121668 @default.
• W2034280908 cites W2018048935 @default.
• W2034280908 cites W2021376393 @default.
• W2034280908 cites W2026122589 @default.
• W2034280908 cites W2027808195 @default.
• W2034280908 cites W2029486574 @default.
• W2034280908 cites W2030625746 @default.
• W2034280908 cites W2043948452 @default.
• W2034280908 cites W2045617883 @default.
• W2034280908 cites W2052245273 @default.
• W2034280908 cites W2052825417 @default.
• W2034280908 cites W2078166953 @default.
• W2034280908 cites W2094075851 @default.
• W2034280908 cites W2107595544 @default.
• W2034280908 cites W2108606693 @default.
• W2034280908 cites W2109591061 @default.
• W2034280908 cites W2116060738 @default.
• W2034280908 cites W2142668543 @default.
• W2034280908 cites W2152993057 @default.
• W2034280908 doi "https://doi.org/10.1016/j.jep.2012.02.023" @default.
• W2034280908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22366676" @default.
• W2034280908 hasPublicationYear "2012" @default.
• W2034280908 type Work @default.
• W2034280908 sameAs 2034280908 @default.
• W2034280908 citedByCount "61" @default.
• W2034280908 countsByYear W20342809082012 @default.
• W2034280908 countsByYear W20342809082013 @default.
• W2034280908 countsByYear W20342809082014 @default.
• W2034280908 countsByYear W20342809082015 @default.
• W2034280908 countsByYear W20342809082016 @default.
• W2034280908 countsByYear W20342809082017 @default.
• W2034280908 countsByYear W20342809082018 @default.
• W2034280908 countsByYear W20342809082020 @default.
• W2034280908 countsByYear W20342809082021 @default.
• W2034280908 countsByYear W20342809082022 @default.
• W2034280908 countsByYear W20342809082023 @default.
• W2034280908 crossrefType "journal-article" @default.
• W2034280908 hasAuthorship W2034280908A5022332504 @default.
• W2034280908 hasAuthorship W2034280908A5026031019 @default.
• W2034280908 hasAuthorship W2034280908A5031224885 @default.
• W2034280908 hasAuthorship W2034280908A5042092772 @default.
• W2034280908 hasAuthorship W2034280908A5043213059 @default.
• W2034280908 hasAuthorship W2034280908A5058556732 @default.
• W2034280908 hasAuthorship W2034280908A5063240353 @default.
• W2034280908 hasAuthorship W2034280908A5069150872 @default.
• W2034280908 hasAuthorship W2034280908A5078863586 @default.
• W2034280908 hasAuthorship W2034280908A5083175225 @default.
• W2034280908 hasConcept C100817775 @default.
• W2034280908 hasConcept C142724271 @default.
• W2034280908 hasConcept C149629883 @default.
• W2034280908 hasConcept C185592680 @default.
• W2034280908 hasConcept C204787440 @default.
• W2034280908 hasConcept C2776148806 @default.
• W2034280908 hasConcept C2778004101 @default.
• W2034280908 hasConcept C2778564307 @default.
• W2034280908 hasConcept C2779054382 @default.
• W2034280908 hasConcept C2780161600 @default.
• W2034280908 hasConcept C31903555 @default.
• W2034280908 hasConcept C43617362 @default.
• W2034280908 hasConcept C4725764 @default.
• W2034280908 hasConcept C55493867 @default.
• W2034280908 hasConcept C556039675 @default.
• W2034280908 hasConcept C71924100 @default.
• W2034280908 hasConcept C97428945 @default.
• W2034280908 hasConceptScore W2034280908C100817775 @default.
• W2034280908 hasConceptScore W2034280908C142724271 @default.
• W2034280908 hasConceptScore W2034280908C149629883 @default.
• W2034280908 hasConceptScore W2034280908C185592680 @default.
• W2034280908 hasConceptScore W2034280908C204787440 @default.
• W2034280908 hasConceptScore W2034280908C2776148806 @default.
• W2034280908 hasConceptScore W2034280908C2778004101 @default.
• W2034280908 hasConceptScore W2034280908C2778564307 @default.
• W2034280908 hasConceptScore W2034280908C2779054382 @default.
• W2034280908 hasConceptScore W2034280908C2780161600 @default.
• W2034280908 hasConceptScore W2034280908C31903555 @default.
• W2034280908 hasConceptScore W2034280908C43617362 @default.

• next