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• W2034281161 abstract "Cyclosporine A (CsA), the most frequently used immunosuppressive drug, has been reported to induce cancer by a cell-autonomous mechanism. Herein, we report that FTY720, a novel immunosuppressant, prevents CsA-induced alterations in both morphology and cell motility at a low concentration (0.1 microM) and induces the CsA-treated cancer cells to undergo apoptosis at a higher concentration (more than 5 microM). The inhibitory activity of FTY720 is unrelated to the decrease of TGF-beta. We believe that a combination treatment with FTY720 and CsA not only results in a synergistic effect on allografts, but also, reduces the incidence of cancer in transplant patients." @default.
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• W2034281161 date "2002-07-01" @default.
• W2034281161 modified "2023-10-06" @default.
• W2034281161 title "A novel immunosuppressive drug, FTY720, prevents the cancer progression induced by cyclosporine" @default.
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• W2034281161 doi "https://doi.org/10.1016/s0304-3835(01)00799-6" @default.
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