FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034281230> ?p ?o ?g. }

• W2034281230 endingPage "728" @default.
• W2034281230 startingPage "718" @default.
• W2034281230 abstract "Objective Growing evidence suggests that fertility-preserving treatment is feasible for young women with early-stage, low-grade endometrial carcinoma. However, published data on their long-term outcomes and prognostic factors remain scanty. We aimed to investigate the outcomes of young women receiving fertility-preserving treatment. Methods Between 1991 and 2010, the outcomes of young women with grade 1 endometrioid endometrial carcinoma at presumed stage IA (without myometrial invasion) who underwent fertility-preserving treatment of megestrol acetate 160 mg/d with or without other hormonal agents were retrospectively analyzed. Results We identified 37 eligible patients (median age, 32 years; range, 18–40 years). The median follow-up time was 78.6 months (range, 19.1–252.8 months). Complete response (CR) lasting more than 6 months was achieved in 30 (81.1%) women. Responders were significantly younger than nonresponders ( P = 0.032). Of the 30 women who had a CR, 15 (50.0%) had disease recurrence. The 5-, 10-, and 15-year cumulative recurrence-free survival rates were 51.0%, 51.0%, and 34.0%, respectively. Notably, those recurred were significantly older ( P = 0.003), and the time to CR was significantly longer ( P = 0.043) than those without recurrence. One patient developed late recurrences at 156 months, and 2 patients developed ovarian metastasis (6 and 137 months from diagnosis). All the patients are currently alive. Conclusions This study demonstrates the feasibility of high-dose megestrol acetate–based therapy for fertility preservation. The substantial risk of late recurrences highlights the need for long-term follow-up studies of large sample sizes with in-depth tumor and host molecular signatures." @default.
• W2034281230 created "2016-06-24" @default.
• W2034281230 creator A5013393479 @default.
• W2034281230 creator A5014223462 @default.
• W2034281230 creator A5014676064 @default.
• W2034281230 creator A5037649723 @default.
• W2034281230 creator A5048454014 @default.
• W2034281230 creator A5054615146 @default.
• W2034281230 creator A5057973652 @default.
• W2034281230 creator A5084426325 @default.
• W2034281230 date "2014-05-01" @default.
• W2034281230 modified "2023-10-14" @default.
• W2034281230 title "Fertility-Preserving Treatment in Young Women With Endometrial Adenocarcinoma: A Long-Term Cohort Study" @default.
• W2034281230 cites W1933506009 @default.
• W2034281230 cites W1970991776 @default.
• W2034281230 cites W1972562420 @default.
• W2034281230 cites W1979945461 @default.
• W2034281230 cites W1992111987 @default.
• W2034281230 cites W2006432458 @default.
• W2034281230 cites W2007160797 @default.
• W2034281230 cites W2017946505 @default.
• W2034281230 cites W2021542768 @default.
• W2034281230 cites W2023127826 @default.
• W2034281230 cites W2023879626 @default.
• W2034281230 cites W2031222466 @default.
• W2034281230 cites W2039043015 @default.
• W2034281230 cites W2039045645 @default.
• W2034281230 cites W2039137970 @default.
• W2034281230 cites W2051304584 @default.
• W2034281230 cites W2064617101 @default.
• W2034281230 cites W2069547854 @default.
• W2034281230 cites W2070969535 @default.
• W2034281230 cites W2112264507 @default.
• W2034281230 cites W2135020195 @default.
• W2034281230 cites W2146896519 @default.
• W2034281230 cites W2149470207 @default.
• W2034281230 cites W2163130168 @default.
• W2034281230 cites W2165948908 @default.
• W2034281230 cites W2324778679 @default.
• W2034281230 doi "https://doi.org/10.1097/igc.0000000000000098" @default.
• W2034281230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24577149" @default.
• W2034281230 hasPublicationYear "2014" @default.
• W2034281230 type Work @default.
• W2034281230 sameAs 2034281230 @default.
• W2034281230 citedByCount "43" @default.
• W2034281230 countsByYear W20342812302014 @default.
• W2034281230 countsByYear W20342812302015 @default.
• W2034281230 countsByYear W20342812302016 @default.
• W2034281230 countsByYear W20342812302017 @default.
• W2034281230 countsByYear W20342812302018 @default.
• W2034281230 countsByYear W20342812302019 @default.
• W2034281230 countsByYear W20342812302020 @default.
• W2034281230 countsByYear W20342812302021 @default.
• W2034281230 countsByYear W20342812302022 @default.
• W2034281230 countsByYear W20342812302023 @default.
• W2034281230 crossrefType "journal-article" @default.
• W2034281230 hasAuthorship W2034281230A5013393479 @default.
• W2034281230 hasAuthorship W2034281230A5014223462 @default.
• W2034281230 hasAuthorship W2034281230A5014676064 @default.
• W2034281230 hasAuthorship W2034281230A5037649723 @default.
• W2034281230 hasAuthorship W2034281230A5048454014 @default.
• W2034281230 hasAuthorship W2034281230A5054615146 @default.
• W2034281230 hasAuthorship W2034281230A5057973652 @default.
• W2034281230 hasAuthorship W2034281230A5084426325 @default.
• W2034281230 hasConcept C121608353 @default.
• W2034281230 hasConcept C126322002 @default.
• W2034281230 hasConcept C167135981 @default.
• W2034281230 hasConcept C205545832 @default.
• W2034281230 hasConcept C2777088508 @default.
• W2034281230 hasConcept C2777904497 @default.
• W2034281230 hasConcept C2780723184 @default.
• W2034281230 hasConcept C2908647359 @default.
• W2034281230 hasConcept C29456083 @default.
• W2034281230 hasConcept C518429986 @default.
• W2034281230 hasConcept C71924100 @default.
• W2034281230 hasConcept C72563966 @default.
• W2034281230 hasConcept C99454951 @default.
• W2034281230 hasConceptScore W2034281230C121608353 @default.
• W2034281230 hasConceptScore W2034281230C126322002 @default.
• W2034281230 hasConceptScore W2034281230C167135981 @default.
• W2034281230 hasConceptScore W2034281230C205545832 @default.
• W2034281230 hasConceptScore W2034281230C2777088508 @default.
• W2034281230 hasConceptScore W2034281230C2777904497 @default.
• W2034281230 hasConceptScore W2034281230C2780723184 @default.
• W2034281230 hasConceptScore W2034281230C2908647359 @default.
• W2034281230 hasConceptScore W2034281230C29456083 @default.
• W2034281230 hasConceptScore W2034281230C518429986 @default.
• W2034281230 hasConceptScore W2034281230C71924100 @default.
• W2034281230 hasConceptScore W2034281230C72563966 @default.
• W2034281230 hasConceptScore W2034281230C99454951 @default.
• W2034281230 hasIssue "4" @default.
• W2034281230 hasLocation W20342812301 @default.
• W2034281230 hasLocation W20342812302 @default.
• W2034281230 hasOpenAccess W2034281230 @default.
• W2034281230 hasPrimaryLocation W20342812301 @default.
• W2034281230 hasRelatedWork W1780935066 @default.
• W2034281230 hasRelatedWork W1958506300 @default.
• W2034281230 hasRelatedWork W1984024102 @default.

• next