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• W2034281555 abstract "A water soluble paclitaxel analogue, the 7-hemisuccinylpaclitaxel, was synthesised and its binding to human serum albumin (HSA) was characterised by difference circular dichroism and optical biosensor methodologies. The carboxylate group was introduced at paclitaxel C-7 position to improve the drug water solubility without significantly changing the biological activity. The paclitaxel analogue showed a relatively low affinity to HSA (3.5×104 M−1), while no significant interactions were evidenced with selective markers for the most characterised binding sites on the carrier, suggesting a non-selective binding to low affinity binding sites." @default.
• W2034281555 created "2016-06-24" @default.
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• W2034281555 date "2003-04-01" @default.
• W2034281555 modified "2023-09-24" @default.
• W2034281555 title "Synthesis and HSA binding characterisation of the water soluble 7-succinylpaclitaxel" @default.
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• W2034281555 doi "https://doi.org/10.1016/s0223-5234(03)00043-6" @default.
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