FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034282428> ?p ?o ?g. }

• W2034282428 endingPage "15" @default.
• W2034282428 startingPage "3" @default.
• W2034282428 abstract "Background Functional dyspepsia (FD), a common functional gastrointestinal disorder, is defined by the Rome III criteria as symptoms of epigastric pain or discomfort (prevalence in FD of 89–90%), postprandial fullness (75–88%), and early satiety (50–82%) within the last 3 months with symptom onset at least 6 months earlier. Patients cannot have any evidence of structural disease to explain symptoms and predominant symptoms of gastroesophageal reflux are exclusionary. Symptoms of FD are non-specific and the pathophysiology is diverse, which explains in part why a universally effective treatment for FD remains elusive. Aim To present current management options for the treatment of FD (therapeutic gain/response rate noted when available). Results The utility of Helicobacter pylori eradication for the treatment of FD is modest (6–14% therapeutic gain), while the therapeutic efficacy of proton pump inhibitors (PPI) (7–10% therapeutic gain), histamine-type-2-receptor antagonists (8–35% therapeutic gain), prokinetic agents (18–45%), tricyclic antidepressants (TCA) (response rates of 64–70%), serotonin reuptake inhibitors (no better than placebo) is limited and hampered by inadequate data. This review discusses dietary interventions and analyses studies involving complementary and alternative medications, and psychological therapies. Conclusions A reasonable treatment approach based on current evidence is to initiate therapy with a daily PPI in H. pylori-negative FD patients. If symptoms persist, a therapeutic trial with a tricyclic antidepressant may be initiated. If symptoms continue, the clinician can possibly initiate therapy with an anti-nociceptive agent, a prokinetic agent, or some form of complementary and alternative medications, although evidence from prospective studies to support this approach is limited." @default.
• W2034282428 created "2016-06-24" @default.
• W2034282428 creator A5024619081 @default.
• W2034282428 creator A5027343826 @default.
• W2034282428 creator A5027535183 @default.
• W2034282428 creator A5034890420 @default.
• W2034282428 creator A5056355381 @default.
• W2034282428 creator A5068302822 @default.
• W2034282428 creator A5077430573 @default.
• W2034282428 creator A5077800751 @default.
• W2034282428 creator A5077959545 @default.
• W2034282428 creator A5086017036 @default.
• W2034282428 date "2012-05-16" @default.
• W2034282428 modified "2023-10-18" @default.
• W2034282428 title "Review article: current treatment options and management of functional dyspepsia" @default.
• W2034282428 cites W1505738485 @default.
• W2034282428 cites W1899229102 @default.
• W2034282428 cites W1964645465 @default.
• W2034282428 cites W1965587137 @default.
• W2034282428 cites W1966133025 @default.
• W2034282428 cites W1966590215 @default.
• W2034282428 cites W1971118578 @default.
• W2034282428 cites W1971613620 @default.
• W2034282428 cites W1975230079 @default.
• W2034282428 cites W1976456647 @default.
• W2034282428 cites W1977331693 @default.
• W2034282428 cites W1978204320 @default.
• W2034282428 cites W1980014064 @default.
• W2034282428 cites W1982864613 @default.
• W2034282428 cites W1984293381 @default.
• W2034282428 cites W1993308285 @default.
• W2034282428 cites W1994438424 @default.
• W2034282428 cites W1996200834 @default.
• W2034282428 cites W2002775833 @default.
• W2034282428 cites W2003068090 @default.
• W2034282428 cites W2003536448 @default.
• W2034282428 cites W2005865101 @default.
• W2034282428 cites W2007494716 @default.
• W2034282428 cites W2010615661 @default.
• W2034282428 cites W2011689449 @default.
• W2034282428 cites W2012441047 @default.
• W2034282428 cites W2012470980 @default.
• W2034282428 cites W2012865161 @default.
• W2034282428 cites W2013352489 @default.
• W2034282428 cites W2014554266 @default.
• W2034282428 cites W2015630427 @default.
• W2034282428 cites W2017364209 @default.
• W2034282428 cites W2021351150 @default.
• W2034282428 cites W2022832699 @default.
• W2034282428 cites W2033053673 @default.
• W2034282428 cites W2037947874 @default.
• W2034282428 cites W2039185599 @default.
• W2034282428 cites W2040773718 @default.
• W2034282428 cites W2049171008 @default.
• W2034282428 cites W2052346133 @default.
• W2034282428 cites W2053937069 @default.
• W2034282428 cites W2058151042 @default.
• W2034282428 cites W2065349462 @default.
• W2034282428 cites W2067877526 @default.
• W2034282428 cites W2068656431 @default.
• W2034282428 cites W2071957690 @default.
• W2034282428 cites W2080646897 @default.
• W2034282428 cites W2083652111 @default.
• W2034282428 cites W2083909172 @default.
• W2034282428 cites W2086872452 @default.
• W2034282428 cites W2088362797 @default.
• W2034282428 cites W2091459554 @default.
• W2034282428 cites W2091704167 @default.
• W2034282428 cites W2096782753 @default.
• W2034282428 cites W2098545746 @default.
• W2034282428 cites W2098801865 @default.
• W2034282428 cites W2101474001 @default.
• W2034282428 cites W2102475453 @default.
• W2034282428 cites W2104427508 @default.
• W2034282428 cites W2105961590 @default.
• W2034282428 cites W2112492459 @default.
• W2034282428 cites W2113101087 @default.
• W2034282428 cites W2129370490 @default.
• W2034282428 cites W2130165677 @default.
• W2034282428 cites W2134113515 @default.
• W2034282428 cites W2137740914 @default.
• W2034282428 cites W2137924300 @default.
• W2034282428 cites W2138391813 @default.
• W2034282428 cites W2138829747 @default.
• W2034282428 cites W2149839188 @default.
• W2034282428 cites W2153335875 @default.
• W2034282428 cites W2157073178 @default.
• W2034282428 cites W2157089605 @default.
• W2034282428 cites W2159988048 @default.
• W2034282428 cites W2166651616 @default.
• W2034282428 cites W2168872194 @default.
• W2034282428 cites W2170457726 @default.
• W2034282428 cites W2232747195 @default.
• W2034282428 cites W4247666381 @default.
• W2034282428 cites W4367160762 @default.
• W2034282428 doi "https://doi.org/10.1111/j.1365-2036.2012.05128.x" @default.
• W2034282428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3970847" @default.
• W2034282428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22591037" @default.

• next