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• W2034283085 abstract "Abstract I g G 4 and I g E are immunoglobulin isotypes which are mediated by the same T h2‐mediated mechanism. The postulated pathogenic and protective function of I g E or I g G 4, respectively, in allergic disease is opposite in parasitic infection. The possible role of I g G 4 against recombinant major allergens on the appearance of different forms of A nisakis simplex ‐associated allergic disease was studied. Gastro‐allergic anisakiasis ( GAA ) and A nisakis ‐sensitization‐associated chronic urticaria ( CU +) were compared for specific I g E , I g G 4 and the respective recognition of A ni s 1 and A ni s 7 . Gastro‐allergic anisakiasis showed higher I g E and I g G 4 levels against crude extract and both recombinant allergens. Whereas I g E recognition of A ni s 7 did not differ and supports both clinical entities to be associated with previous acute parasitism, the I g E recognition rates of A ni s 1 and I g G 4 recognition of both A ni s 1 and A ni s 7 were higher in GAA . I g G 4 levels were associated with I g E , but also with age, time to last parasitic episode and frequency of fish intake. Logistic regression analysis showed that the presence of specific I g G 4 against A ni s 7 was an independent marker associated with GAA . In the diagnosis of A nisakis ‐associated allergic disease phenotypes ( GAA versus CU +), measurement of specific I g G 4 against recombinant allergens could be useful. Further, evaluation of specific I g E and I g G 4 facilitates more insight into the protective versus pathogenic potential of I g E and I g G 4 ." @default.
• W2034283085 created "2016-06-24" @default.
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• W2034283085 date "2014-01-23" @default.
• W2034283085 modified "2023-10-14" @default.
• W2034283085 title "Specific IgG₄: Possible Role in the Pathogenesis and a New Marker in the Diagnosis of<i>Anisakis</i>-associated Allergic Disease" @default.
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• W2034283085 doi "https://doi.org/10.1111/sji.12129" @default.
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