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- W2034284060 abstract "The effects on gastric mucosal permeability (GMP) of the topical application and intravenous administration of prostaglandin E 2 (PGE 2 ), 15(S)-15-methyl prostaglandin E 2 (15M), and 16,16-dimethyl prostaglandin E 2 (16DM) were measured in canine Heidenhain pouches. Two groups of four dogs were used and each experiment consisted of a 3-h perfusion with an acid saline solution containing polyethylene glycol as a volume marker. The prostaglandin was either added to the perfusate or given by constant intravenous infusion. The H + and Na + fluxes were used to assess GMP. Topical (1–10 μg/mL) and intravenous (0.3–1.2 μg kg −1 h −1 ) 16DM increased the apparent Na + flux into the pouch in association with the secretion of fluid by the pouches, but did not alter H+ flux. The PGE 2 applied topically (10–1000 μg/mL) had a similar effect, but intravenously (0.3–1.2 mg kg −1 h −1 ) reduced the volume of pouch secretion and the apparent Na + flux into the pouch without altering H + flux. The 15M given in the same concentration as 16DM was without a consistent effect on ionic flux or volume of secretion. The E 2 prostaglandins have no effect on normal GMP." @default.
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- W2034284060 title "Permeability effects of the E2 prostaglandins on canine gastric mucosa" @default.
- W2034284060 doi "https://doi.org/10.1139/y79-162" @default.
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