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• W2034285282 abstract "ATP-binding cassette (ABC) transporter multidrug resistance protein 4 (MRP4, ABCC4) is involved in multidrug resistance (MDR), which is an increasing challenge to the treatment of cancer and infections. We have constructed a molecular model of ABCC4 based on the outward facing Sav1866 crystal structure using molecular modeling techniques. Amino acids reported by ICMPocketFinder to take part in substrate translocation were among others Glu103 (TMH1), Ser328 (TMH5), Gly359 (TMH6), Arg362 (TMH6), Val726 (TMH7), and Leu987 (TMH12), and their corresponding amino acids in ABCB1 (P-glycoprotein) have been reported to be involved in drug binding according to site-directed mutagenesis studies. The ABCC4 model may be used as a working tool for experimental studies on ABCC4 and design of more specific membrane transport modulating agents (MTMA)." @default.
• W2034285282 created "2016-06-24" @default.
• W2034285282 creator A5007069291 @default.
• W2034285282 creator A5060635863 @default.
• W2034285282 date "2008-06-01" @default.
• W2034285282 modified "2023-10-15" @default.
• W2034285282 title "Molecular model of the outward facing state of the human multidrug resistance protein 4 (MRP4/ABCC4)" @default.
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• W2034285282 doi "https://doi.org/10.1016/j.bmcl.2008.05.047" @default.
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