FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034286175> ?p ?o ?g. }

• W2034286175 endingPage "54" @default.
• W2034286175 startingPage "44" @default.
• W2034286175 abstract "Human and veterinarian pharmaceuticals have been detected in the aquatic environment for a number of years, but the potential for biological effects in exposed aquatic organism is only now being reported. The lipid regulator, gemfibrozil (GEM) is detected at μg/L concentrations in domestic wastewater and ng/L concentrations in surface waters. We investigated the uptake of GEM in goldfish ( Carassius auratus ) over a 96 h time period by measuring GEM in blood plasma using LC–MS/MS. Results indicated that GEM can be taken up from water through the gills. In goldfish exposed to GEM by a single intraperitoneal injection, concentrations of GEM in the blood plasma declined rapidly over 96 h post-injection, with a half-life estimated at approximately 19 h. Exposure of goldfish to waterborne GEM at an environmentally relevant concentration over 14 days resulted in a plasma bioconcentration factor of 113. In goldfish exposed to aqueous concentrations of GEM for 96 h or 14 days, plasma testosterone (T) was reduced by over 50% in fish from all treatments. As a possible mechanistic explanation for the observed reduction in T, levels of steroid acute regulatory (StAR) protein transcript in goldfish testes were assessed by RT–PCR. StAR protein is involved in the transport of cholesterol from the outer to the inner mitochondrial membrane for transformation by the first enzyme in steroidogenesis. After exposure to GEM for 96 h, a 50% decrease in StAR mRNA levels was observed in goldfish. Gonadal StAR mRNA levels were not affected in the 14 days exposure, indicating that the observed decreases in plasma testosterone were not solely due to impaired delivery of cholesterol to the inner mitochondrial membrane. Our results demonstrate that exposure to environmental levels of GEM leads to bioconcentration of the drug in plasma and the potential for endocrine disruption in fish." @default.
• W2034286175 created "2016-06-24" @default.
• W2034286175 creator A5004819710 @default.
• W2034286175 creator A5007839244 @default.
• W2034286175 creator A5008840067 @default.
• W2034286175 creator A5015323485 @default.
• W2034286175 creator A5079534276 @default.
• W2034286175 creator A5083929705 @default.
• W2034286175 date "2005-06-01" @default.
• W2034286175 modified "2023-10-06" @default.
• W2034286175 title "The human lipid regulator, gemfibrozil bioconcentrates and reduces testosterone in the goldfish, Carassius auratus" @default.
• W2034286175 cites W1516525411 @default.
• W2034286175 cites W1608086260 @default.
• W2034286175 cites W1973814811 @default.
• W2034286175 cites W1999296233 @default.
• W2034286175 cites W2003432885 @default.
• W2034286175 cites W2010708771 @default.
• W2034286175 cites W2011994682 @default.
• W2034286175 cites W2032838523 @default.
• W2034286175 cites W2033296044 @default.
• W2034286175 cites W2033524588 @default.
• W2034286175 cites W2034262530 @default.
• W2034286175 cites W2036582121 @default.
• W2034286175 cites W2036949163 @default.
• W2034286175 cites W2037360988 @default.
• W2034286175 cites W2037766564 @default.
• W2034286175 cites W2041283704 @default.
• W2034286175 cites W2044810460 @default.
• W2034286175 cites W2044833898 @default.
• W2034286175 cites W2053322034 @default.
• W2034286175 cites W2069563927 @default.
• W2034286175 cites W2087950507 @default.
• W2034286175 cites W2090166415 @default.
• W2034286175 cites W2099485641 @default.
• W2034286175 cites W2104295111 @default.
• W2034286175 cites W2132366559 @default.
• W2034286175 cites W2147322409 @default.
• W2034286175 cites W2160284634 @default.
• W2034286175 cites W2164091619 @default.
• W2034286175 cites W2164098477 @default.
• W2034286175 cites W4230949657 @default.
• W2034286175 cites W4237867692 @default.
• W2034286175 cites W4237964466 @default.
• W2034286175 doi "https://doi.org/10.1016/j.aquatox.2005.01.009" @default.
• W2034286175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15892991" @default.
• W2034286175 hasPublicationYear "2005" @default.
• W2034286175 type Work @default.
• W2034286175 sameAs 2034286175 @default.
• W2034286175 citedByCount "209" @default.
• W2034286175 countsByYear W20342861752012 @default.
• W2034286175 countsByYear W20342861752013 @default.
• W2034286175 countsByYear W20342861752014 @default.
• W2034286175 countsByYear W20342861752015 @default.
• W2034286175 countsByYear W20342861752016 @default.
• W2034286175 countsByYear W20342861752017 @default.
• W2034286175 countsByYear W20342861752018 @default.
• W2034286175 countsByYear W20342861752019 @default.
• W2034286175 countsByYear W20342861752020 @default.
• W2034286175 countsByYear W20342861752021 @default.
• W2034286175 countsByYear W20342861752022 @default.
• W2034286175 countsByYear W20342861752023 @default.
• W2034286175 crossrefType "journal-article" @default.
• W2034286175 hasAuthorship W2034286175A5004819710 @default.
• W2034286175 hasAuthorship W2034286175A5007839244 @default.
• W2034286175 hasAuthorship W2034286175A5008840067 @default.
• W2034286175 hasAuthorship W2034286175A5015323485 @default.
• W2034286175 hasAuthorship W2034286175A5079534276 @default.
• W2034286175 hasAuthorship W2034286175A5083929705 @default.
• W2034286175 hasConcept C104488531 @default.
• W2034286175 hasConcept C107872376 @default.
• W2034286175 hasConcept C126322002 @default.
• W2034286175 hasConcept C134018914 @default.
• W2034286175 hasConcept C161153951 @default.
• W2034286175 hasConcept C185592680 @default.
• W2034286175 hasConcept C18903297 @default.
• W2034286175 hasConcept C2779279991 @default.
• W2034286175 hasConcept C2780159080 @default.
• W2034286175 hasConcept C2909208804 @default.
• W2034286175 hasConcept C29730261 @default.
• W2034286175 hasConcept C2994357808 @default.
• W2034286175 hasConcept C505870484 @default.
• W2034286175 hasConcept C61952481 @default.
• W2034286175 hasConcept C71572567 @default.
• W2034286175 hasConcept C71924100 @default.
• W2034286175 hasConcept C86803240 @default.
• W2034286175 hasConceptScore W2034286175C104488531 @default.
• W2034286175 hasConceptScore W2034286175C107872376 @default.
• W2034286175 hasConceptScore W2034286175C126322002 @default.
• W2034286175 hasConceptScore W2034286175C134018914 @default.
• W2034286175 hasConceptScore W2034286175C161153951 @default.
• W2034286175 hasConceptScore W2034286175C185592680 @default.
• W2034286175 hasConceptScore W2034286175C18903297 @default.
• W2034286175 hasConceptScore W2034286175C2779279991 @default.
• W2034286175 hasConceptScore W2034286175C2780159080 @default.
• W2034286175 hasConceptScore W2034286175C2909208804 @default.
• W2034286175 hasConceptScore W2034286175C29730261 @default.
• W2034286175 hasConceptScore W2034286175C2994357808 @default.
• W2034286175 hasConceptScore W2034286175C505870484 @default.

• next