FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034287728> ?p ?o ?g. }

• W2034287728 endingPage "635" @default.
• W2034287728 startingPage "629" @default.
• W2034287728 abstract "1 Two polydeoxyribonucleotides, produced by the controlled hydrolysis of DNA of mammalian lung (defibrotide and its lower molecular weight fraction, P.O. 085 DV), were studied for their ability to modify the release of nitrite and the coronary flow in perfusates collected from isolated, normally perfused hearts of guinea-pigs and from hearts subjected to regional ischaemia and reperfusion. 2 In guinea-pig normally perfused hearts, both defibrotide (DFT) and its fraction, P.O. 085 DV, increase the amount of nitrite appearing in perfusates in a concentration-dependent fashion. At the highest concentration studied (10−6 m), P.O. 085 DV was more effective than DFT. A concomitant increase in the coronary flow was observed. 3 The increase in nitrite in perfusates and the increase in coronary flow induced by both DFT and P.O. 085 DV were significantly reduced by NGmonomethyl-L-arginine (l-NMMA, 10−4 m), an inhibitor of nitric oxide synthase (NOS). 4 The endothelium-dependent vasodilator, acetylcholine (ACh), enhances the formation of nitrite and the coronary flow. Both the increase in coronary flow and in the formation of nitrite were significantly reduced by L-NMMA (10−4 m). 5 In guinea-pig hearts subjected to ischaemia and reperfusion, the effect of both compounds in increasing the amount of nitrite in perfusates was more evident and more pronounced with P.O. 085 DV. 6 Reperfusion-induced arrhythmias were significantly reduced by both compounds to the extent of complete protection afforded by compound P.O. 085 DV. 7 The cardioprotective and antiarrhythmic effects of DFT and P.O. 085 DV are discussed." @default.
• W2034287728 created "2016-06-24" @default.
• W2034287728 creator A5012124630 @default.
• W2034287728 creator A5015241973 @default.
• W2034287728 creator A5048678528 @default.
• W2034287728 creator A5051403621 @default.
• W2034287728 creator A5085432684 @default.
• W2034287728 date "1995-06-01" @default.
• W2034287728 modified "2023-09-25" @default.
• W2034287728 title "Polydeoxyribonucleotides and nitric oxide release from guinea-pig hearts during ischaemia and reperfusion" @default.
• W2034287728 cites W1042881234 @default.
• W2034287728 cites W106540947 @default.
• W2034287728 cites W169761074 @default.
• W2034287728 cites W1977378988 @default.
• W2034287728 cites W1985371194 @default.
• W2034287728 cites W1992043172 @default.
• W2034287728 cites W2007348055 @default.
• W2034287728 cites W2007737411 @default.
• W2034287728 cites W2011233979 @default.
• W2034287728 cites W2013159566 @default.
• W2034287728 cites W2014791861 @default.
• W2034287728 cites W2017955971 @default.
• W2034287728 cites W2044738898 @default.
• W2034287728 cites W2047959026 @default.
• W2034287728 cites W2058137293 @default.
• W2034287728 cites W2068549489 @default.
• W2034287728 cites W2069174503 @default.
• W2034287728 cites W2070134655 @default.
• W2034287728 cites W2082964670 @default.
• W2034287728 cites W2084232992 @default.
• W2034287728 cites W2088673224 @default.
• W2034287728 cites W2103379524 @default.
• W2034287728 cites W2110897988 @default.
• W2034287728 cites W2143183230 @default.
• W2034287728 cites W2244634594 @default.
• W2034287728 cites W2295853503 @default.
• W2034287728 cites W2399326962 @default.
• W2034287728 cites W2403971289 @default.
• W2034287728 cites W2409856369 @default.
• W2034287728 cites W2412902561 @default.
• W2034287728 cites W2427074402 @default.
• W2034287728 cites W2466163118 @default.
• W2034287728 cites W2466775910 @default.
• W2034287728 cites W2484154641 @default.
• W2034287728 cites W4376453479 @default.
• W2034287728 doi "https://doi.org/10.1111/j.1476-5381.1995.tb14978.x" @default.
• W2034287728 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1908494" @default.
• W2034287728 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7582482" @default.
• W2034287728 hasPublicationYear "1995" @default.
• W2034287728 type Work @default.
• W2034287728 sameAs 2034287728 @default.
• W2034287728 citedByCount "23" @default.
• W2034287728 countsByYear W20342877282013 @default.
• W2034287728 countsByYear W20342877282014 @default.
• W2034287728 countsByYear W20342877282015 @default.
• W2034287728 countsByYear W20342877282016 @default.
• W2034287728 countsByYear W20342877282017 @default.
• W2034287728 countsByYear W20342877282018 @default.
• W2034287728 crossrefType "journal-article" @default.
• W2034287728 hasAuthorship W2034287728A5012124630 @default.
• W2034287728 hasAuthorship W2034287728A5015241973 @default.
• W2034287728 hasAuthorship W2034287728A5048678528 @default.
• W2034287728 hasAuthorship W2034287728A5051403621 @default.
• W2034287728 hasAuthorship W2034287728A5085432684 @default.
• W2034287728 hasBestOaLocation W20342877281 @default.
• W2034287728 hasConcept C120770815 @default.
• W2034287728 hasConcept C126322002 @default.
• W2034287728 hasConcept C158846371 @default.
• W2034287728 hasConcept C178790620 @default.
• W2034287728 hasConcept C185592680 @default.
• W2034287728 hasConcept C2776157398 @default.
• W2034287728 hasConcept C2776179834 @default.
• W2034287728 hasConcept C2776384668 @default.
• W2034287728 hasConcept C2776992346 @default.
• W2034287728 hasConcept C2777622882 @default.
• W2034287728 hasConcept C2778815084 @default.
• W2034287728 hasConcept C519581460 @default.
• W2034287728 hasConcept C541997718 @default.
• W2034287728 hasConcept C71924100 @default.
• W2034287728 hasConcept C98274493 @default.
• W2034287728 hasConceptScore W2034287728C120770815 @default.
• W2034287728 hasConceptScore W2034287728C126322002 @default.
• W2034287728 hasConceptScore W2034287728C158846371 @default.
• W2034287728 hasConceptScore W2034287728C178790620 @default.
• W2034287728 hasConceptScore W2034287728C185592680 @default.
• W2034287728 hasConceptScore W2034287728C2776157398 @default.
• W2034287728 hasConceptScore W2034287728C2776179834 @default.
• W2034287728 hasConceptScore W2034287728C2776384668 @default.
• W2034287728 hasConceptScore W2034287728C2776992346 @default.
• W2034287728 hasConceptScore W2034287728C2777622882 @default.
• W2034287728 hasConceptScore W2034287728C2778815084 @default.
• W2034287728 hasConceptScore W2034287728C519581460 @default.
• W2034287728 hasConceptScore W2034287728C541997718 @default.
• W2034287728 hasConceptScore W2034287728C71924100 @default.
• W2034287728 hasConceptScore W2034287728C98274493 @default.
• W2034287728 hasIssue "4" @default.
• W2034287728 hasLocation W20342877281 @default.
• W2034287728 hasLocation W20342877282 @default.

• next