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• W2034287995 abstract "Epidermal growth factor receptor (EGFR) is a cell surface molecule and member of the ErbB family of receptor tyrosine kinases. Its activation leads to proliferation, antiapoptosis, and metastatic spread, making inhibition of this pathway a compelling target. In recent years, an increasing number of clinical trials in the management of solid malignancies have become available indicating the clinical efficacy of anti-EGFR monoclonal antibodies and oral small molecule tyrosine kinase inhibitors (TKIs). This review addresses frequently used EGFR inhibitors, summarizes clinical efficacy data of these new therapeutic agents, and discusses their associated toxicity and management." @default.
• W2034287995 created "2016-06-24" @default.
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• W2034287995 creator A5033720905 @default.
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• W2034287995 date "2009-01-01" @default.
• W2034287995 modified "2023-10-14" @default.
• W2034287995 title "Clinical Efficacy and Toxicity of Anti-EGFR Therapy in Common Cancers" @default.
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• W2034287995 doi "https://doi.org/10.1155/2009/567486" @default.
• W2034287995 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2677718" @default.
• W2034287995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19424511" @default.
• W2034287995 hasPublicationYear "2009" @default.
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