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• W2034288413 endingPage "11797" @default.
• W2034288413 startingPage "11792" @default.
• W2034288413 abstract "Natural killer (NK) cells are inhibited from killing cellular targets by major histocompatibility complex (MHC) class I molecules. In the mouse, this can be mediated by the Ly-49A NK cell receptor that specifically binds the H-2Dd MHC class I molecule, then inhibits NK cell activity. Previous experiments have indicated that Ly-49A recognizes the alpha 1/alpha 2 domains of MHC class I and that no specific MHC-bound peptide appeared to be involved. We demonstrate here that alanine-substituted peptides, having only the minimal anchor motifs, stabilized H-2Dd expression and provided resistance to H-2Dd-transfected, transporter associated with processing (TAP)-deficient cells from lysis by Ly-49A+ NK cells. Peptide-induced resistance was blocked only by an mAb that binds a conformational determinant on H-2Dd. Moreover, stabilization of empty H-2Dd heavy chains by exogenous beta 2-microglobulin did not confer resistance. In contrast to data for MHC class I-restricted T cells that are specific for peptides displayed MHC molecules, these data indicate that NK cells are specific for a peptide-induced conformational determinant, independent of specific peptide. This fundamental distinction between NK cells and T cells further implies that NK cells are sensitive only to global changes in MHC class I conformation or expression, rather than to specific pathogen-encoded peptides. This is consistent with the missing self hypothesis, which postulates that NK cells survey tissues for normal expression of MHC class I." @default.
• W2034288413 created "2016-06-24" @default.
• W2034288413 creator A5019023491 @default.
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• W2034288413 creator A5076848381 @default.
• W2034288413 date "1996-10-15" @default.
• W2034288413 modified "2023-09-26" @default.
• W2034288413 title "The natural killer cell receptor Ly-49A recognizes a peptide-induced conformational determinant on its major histocompatibility complex class I ligand." @default.
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• W2034288413 doi "https://doi.org/10.1073/pnas.93.21.11792" @default.
• W2034288413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/38137" @default.
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• W2034288413 hasPublicationYear "1996" @default.
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